64622-45-3

Name	2-pyridylmethyl 2-(4-isobutylphenyl)propionate
Synonyms	BE 100 Vesicum Staderm U 75630 Pimeprofen Ibuprofenpiconol Ibuprofen piconol (U75630) 2-pyridylmethyl 2-(4-isobutylphenyl)propionate 2-(p-Isobutylphenyl)propionic acid 2-pyridylmethyl ester
CAS	64622-45-3
EINECS	264-979-8

Molecular Formula	C19H23NO2
Molar Mass	297.4
Density	1.0971 (rough estimate)
Boling Point	438.9°C (rough estimate)
Solubility	Acetone (Slightly), Chloroform (Slightly), Methanol (Sparingly)
Appearance	Oil
Color	Colourless
pKa	3.36±0.12(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.5000 (estimate)
In vitro study	Ibuprofen piconol is a chemically stable, slightly hygroscopic liquid that strongly partitions into the oil phase and shows no indication of surface activity. This drug has very limited solubility in water (16.5 ppm), modest solubility in glycerol (16.4 mg/mL), and is miscible with less polar organics except for silicone fluids. Varying the initial concentration of ibuprofen piconol does not alter the hydrolysis half-life (concentration range from 50 to 200 μg/mL). The anticoagulant used alters the hydrolysis half-life. For plasma, the half-life is shortest when no anticoagulant is present (t 1/2 =2.5 h) and longer with the presence of anticoagulants; t 1/2 =8.0 h for citrate, t 1/2 =15.5 h for heparin and t 1/2 =161.8 h for EDTA. Red blood cell uptake of ibuprofen piconol is minimal and ranges from 0.4 to 4.1% over the ibuprofen piconol concentrations used in the study.
In vivo study	When ibuprofen piconol is applied topically, only ibuprofen and its metabolites are observed in plasma and urine. The conversion of ibuprofen piconol to ibuprofen appears to be extremely rapid in vivo .

Last Update：2024-01-02 23:10:35

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Product Name: 2-pyridylmethyl 2-(4-isobutylphenyl)propionate Visit Supplier Webpage Request for quotation
CAS: 64622-45-3
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QQ: 3008007409

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64622-45-3

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