65-45-2
Salicylamide
CAS: 65-45-2
Molecular Formula: C7H7NO2
65-45-2 - Names and Identifiers
| Name | Salicylamide |
| Synonyms | SAM Samid Acket salrin urtosal salicim salymid salipur saliamin Afko-Sal Salamide salizell LABEIM-A SALICYLAMIDE Salicylamide O-hydroxy amide 2-Carbamoylphenol 2-hydroxybenzamide 2-hydroxy-benzamid 2-HYDROXYBENZAMIDE O-HYDROXYBENZAMIDE 2-hydroxy formamide 2-hydroxy Benzamide O-dyhroxy-formamide 2-hydroxy benzylamine 2-hydroxy-benzoicaciamide Deferasirox Benzamide Impurity Salicylamide o-Hydroxybenzamide Salamide |
| CAS | 65-45-2 |
| EINECS | 200-609-3 |
| InChI | InChI=1/C7H7NO2/c8-7(10)5-3-1-2-4-6(5)9/h1-4,9H,(H2,8,10) |
| InChIKey | SKZKKFZAGNVIMN-UHFFFAOYSA-N |
65-45-2 - Physico-chemical Properties
| Molecular Formula | C7H7NO2 |
| Molar Mass | 137.14 |
| Density | 1,175 g/cm3 |
| Melting Point | 140-144°C(lit.) |
| Boling Point | 270°C |
| Flash Point | 181°C/14mm |
| Water Solubility | <0.1 g/100 mL at 20 ºC |
| Solubility | methanol: 0.1g/mL, clear |
| Vapor Presure | 0.000195mmHg at 25°C |
| Appearance | White powder |
| Color | White |
| Odor | Odorless |
| Merck | 14,8328 |
| BRN | 742439 |
| pKa | pKa 8.13(H2Ot = 37) (Uncertain) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Stability | Stable. Light sensitive. Incompatible with strong bases, strong oxidizing agents. |
| Sensitive | Sensitive to light |
| Refractive Index | 1.5323 (estimate) |
| MDL | MFCD00007978 |
| Physical and Chemical Properties | Melting point 139-142°C boiling point 270°C water-soluble <0.1g/100 mL at 20°C White or micro-pink crystalline powder, odorless and tasteless, slightly soluble in ethanol or glycerol, insoluble in water, soluble in sodium hydroxide solution, the aqueous solution was acidic reaction, slightly bitter. |
| Use | Antipyretic analgesic, for Fever Head Pain, neuralgia, Arthralgia and active rheumatism and other diseases; This product is antipyretic analgesic, for Fever Head Pain, neuralgia, Arthralgia and active rheumatism. This product is also other pharmaceuticals, pesticides and other fine chemicals intermediates. |
65-45-2 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| UN IDs | 3249 |
| WGK Germany | 3 |
| RTECS | VN6475000 |
| TSCA | Yes |
| HS Code | 29214300 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | LD50 orally in mice: 1.4 g/kg (Hart) |
65-45-2 - Upstream Downstream Industry
| Raw Materials | Methyl salicylate Methyl salicylate Ammonia |
| Downstream Products | 5-Acetylsalicylamide Labetalol |
65-45-2 - Introduction
Slightly soluble in ethanol or glycerin, the solubility in water is 0-2% at 30 ℃ and 0-8% at 47 ℃. The solubility in glycerol is 2-0% at 5 ℃, 5-0% at 39 ℃ and 10-0% at 60 ℃. Soluble in hot water, ethanol, ether and chloroform, slightly soluble in cold water, soluble in sodium hydroxide solution, the aqueous solution is acidic and slightly bitter. The pH of saturated aqueous solution at 28 ℃ is about 5, and the pH of sodium salt in aqueous solution is 9. Toxic, half lethal dose (mice, oral) 1 · 4g/kg. It's irritating.
Last Update：2022-10-16 17:27:43
65-45-2 - Reference Information
| background | the scientific name of salicylamide is 2-hydroxybenzoformamide, which is a very important organic synthesis intermediate and is a raw material for the synthesis of many important derivatives (such as spironcide nitroaniline, analgesic and antiheat, etc.). It is widely used in medicine, spices, dyes, many fields of rubber additives. Salicylamide is not only an important fine chemical intermediate, but also a widely accepted and widely used antipyretic analgesic sub, used for fever, headache, neuralgia, arthralgia and or active rheumatism, etc. |
| application | salicylamide is a widely used fine chemical intermediate. it can be used to synthesize organic chemicals such as nifediamine and o-ethoxyformamide, and is also commonly used in the fields of medical treatment, perfume, fuel and rubber additives, at the same time, salicylamide is a widely used antipyretic analgesic, which can be used to treat fever, headache, neuralgia, joint pain and rheumatic joint pain. |
| preparation | a preparation method of salicylamide, adding 150kg of methyl salicylate and 420kg of toluene to a 1000-liter stainless steel reactor, heating to 40-45 ℃, continuously passing ammonia for ammonification reaction, and controlling the reaction temperature at 40-45 ℃, the reaction pressure is controlled at 0.25~0.35MPa, ammonia gas is stopped after ammoniation reaction for 5 hours, toluene and reaction by-product methanol are heated and recovered, the remaining material is cooled to 20 ℃, salicylamide is obtained after crystallization and centrifugation, and the yield is 97.8%. |
| chemical properties | white or micronized red crystalline powder. Melting point 140 ℃. Easily soluble in hot water, alcohol, ether and chloroform, slightly soluble in cold water. The pH of saturated aqueous solution at 28 ℃ is about 5. Slightly bitter. |
| use | antipyretic analgesic for fever, headache, neuralgia, arthralgia, active rheumatism and other diseases when used for antipyretic analgesia, adults 0.3~0.5g, 3~4 times a day. When used for anti-inflammatory, 1~2g, once every 4~6 hours, 3~6 days as a course of treatment. |
| production method | this product has certain antipyretic, analgesic and anti-inflammatory effects, but its curative effect is worse than aspirin. It does not decompose in the stomach and has little irritation to the stomach. Suitable for fever, headache, neuralgia, arthralgia and active rheumatism. |
| NIST chemical information | The information is: webbook.nist.gov provides (external link) |
| EPA chemical information | The information is: ofmpub.epa.gov provides (external link) |
| toxic substance data | The information is: pubchem.ncbi.nlm.nih.gov Provide (external link) |
Last Update：2024-04-09 01:59:58
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Raw Materials for 65-45-2
Downstream Products for 65-45-2