65497-07-6
Esculentoside A
CAS: 65497-07-6
Molecular Formula: C42H66O16
65497-07-6 - Names and Identifiers
| Name | Esculentoside A |
| Synonyms | Esculentoside Esculentoside A ESCULENTOSIDE A 4-O-(2,23,28-trihydroxy-29-methoxy-28,29-dioxoolean-12-en-3-yl)pentopyranosyl hexopyranoside Olean-12-ene-28,29-dioic acid, 3-[(4-O-β-D-glucopyranosyl-β-D-xylopyranosyl)oxy]-2,23-dihydroxy-, 29-methyl ester, (2β,3β,4α,20β)- (2b,3b,4a,20b)-3-((4-O-beta-D-Glucopyranosyl-beta-D-xylopyranosyl)oxy)-2,23-dihydroxyolean-12-ene-28,29-dioic acid 29-methyl ester |
| CAS | 65497-07-6 |
| InChI | InChI=1/C42H66O16/c1-37(36(53)54-6)11-13-42(35(51)52)14-12-40(4)20(21(42)15-37)7-8-26-38(2)16-22(45)32(39(3,19-44)25(38)9-10-41(26,40)5)56-24-18-55-33(30(49)28(24)47)58-34-31(50)29(48)27(46)23(17-43)57-34/h7,21-34,43-50H,8-19H2,1-6H3,(H,51,52) |
65497-07-6 - Physico-chemical Properties
| Molecular Formula | C42H66O16 |
| Molar Mass | 826.96 |
| Density | 1.42±0.1 g/cm3(Predicted) |
| Melting Point | >192°C (dec.) |
| Boling Point | 936.7±65.0 °C(Predicted) |
| Specific Rotation(α) | +51.3 (c, 0.99 in EtOH) |
| Flash Point | 275.3°C |
| Solubility | Soluble in DMSO |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | Colorless needle crystal |
| Color | Pale Yellow |
| pKa | 4.39±0.70(Predicted) |
| Storage Condition | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| Stability | Hygroscopic |
| Refractive Index | 1.619 |
| MDL | MFCD27980582 |
| Physical and Chemical Properties | White crystalline powder, soluble in water, hot methanol and ethanol, n-butanol, insoluble in acetone, ether and other lipophilic solvents, derived from pokeweed Phytolacca acinosa Roxb. |
| In vitro study | Esculentoside A (0-10 μM; 24 hours) reduced the release of TNF concentration in primed macrophages . |
| In vivo study | Esculentoside A (EsA) (intraperitoneal injection; 20 mg/kg; once a day; 4 weeks) plays significant roles in the treatment of BXSB mice through modulation of inflammatory cytokines, inhibition of renal cell proliferation and induction of apoptosis . Esculentoside A (EsA) (injected intraperitoneally; 5, 10 and 20 mg/kg; once a day; 7 days) dose-dependently decreases the TNF, IL-1 and IL-6 levels in the sera of mice following LPS challenge. Animal Model: BXSB mice Dosage: 20 mg/kg Administration: Intraperitoneal injection; 20 mg/kg; once a day; 4 weeks Result: Alleviated the renal damage of LN. |
65497-07-6 - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| HS Code | 29389090 |
65497-07-6 - Reference
| Reference Show more | 1. Zhou Qilin, LV Weiqi, Tang shengling. Variation of water-soluble extract and pokeweed saponin a content and selection of superior provenances [J]. Chinese Journal of Experimental prescriptions, 2018, 024(004):44-50. 2. Tang Jie, Yin, Zhang Wei, Zhang Xianggui et al. Effect of pokeweed saponin A on differentiation of CD4 ~ T cells into Th17 [J]. Basic and Clinical Medicine 2019 v.39(12):98-100. 3. Tang Jie, Yin, Zhang Wei, Zhang Xianggui et al. Effect of pokeweed saponin A on proliferation of Glomerular mesangial cells induced by IL-17 [J]. Shaanxi traditional Chinese medicine 2019 040(007):819-822. 4. Tang Jie Yin Dong Yang Zhang Xiang Gui Xiao Han Zhang Wei Xu Lijun. Effects of pokeweed saponin A on activation of ERK pathway induced by IL-1β in Glomerular mesangial cells [J]. Guangdong Medical 2016 37(11):1613-1617. 5. Qiu Mingming, Wu Hao, Yu Hongli, etc. Study on integrated processing technology of producing area and processing of pokeweed pieces [J]. Central South pharmacy 2018 v.16;No.148(05):36-39. 6. Zhang Cong, Liu Chuanxin, Wang mingshuang, etc. Study on the mechanism of HKC cell injury induced by pokeweed saponin a based on cell metabolomics [J]. Chinese scientific and technological data catalogue-Chinese herbal medicine, 2020, 043(003):443-450. 7. Yang Xue, Liu Chuanxin, Fu-Li Yuan, et al. Study on the mechanism of kidney injury induced by pokeweed in rats based on network toxicology. 8. Zhao Lei, Ding Piying, Zheng Xing, et al. Antibacterial Activity and tyrosinase inhibitory activity of different polar parts of quinoa Bran [J]. Science and Technology of food industry, 2019, 040(006):82-88,94. 9. Lei Zhao, Xiaona Li, Longlong Shi, et al. Determination of nutritional components of quinoa Bran and antioxidant activity of its oil [J]. Modern food science and technology, 2019, v.35;No.243(11):157 205-211. 10. Du Zhengcai, Xia Zhongshang, Weeman, et al. Study on quality control of Pueraria Jiangtang capsules based on UPLC combined with colorimetry [J]. Chinese herbal medicine, 2019, v.50;No.656(21):147-153. 11. Mao-Sen Zeng, Wen-Di Yu, Hui-Xian Wang, Jin-Yuan Liu, Pei-Ping Xu,A potential antiviral activity of Esculentoside A against binding interactions of SARS-COV-2 spike protein and angiotensin converting enzyme 2 (ACE2),International Journal of Biological Ma 12. [IF=6.953] Mao-Sen Zeng et al."A potential antiviral activity of Esculentoside A against binding interactions of SARS-COV-2 spike protein and angiotensin converting enzyme 2 (ACE2)."Int J Biol Macromol. 2021 Jul;183:2248 13. [IF=3.642] Tao He et al."Integrating non-targeted metabolomics and toxicology networks to study the mechanism of Esculentoside A- induced hepatotoxicity in rats."J Biochem Mol Toxic. 2021 Jun;35(6):1-15 14. [IF=2.863] Peng Xue et al."Reducing the damage of quinoa saponins on human gastric mucosal cells by a heating process."Food Sci Nutr. 2020 Jan;8(1):500-510 |
65497-07-6 - Reference Information
| action | the active ingredient of pokeweed saponin has many pharmacological effects such as anti-inflammatory, immune enhancement, anti-tumor and so on, with pokeweed saponin a having the highest content. |
| application | pokeweed saponin a has anti-inflammatory, anti-apoptosis and anti-tumor cell proliferation effects in a variety of acute and chronic models. Pokeweed saponin A can alleviate LPS-induced acute lung injury by inhibiting the production of inflammatory factors, and at the same time can reduce the release of NO caused by LPS. In addition, as an Nrf2 activator, pokeweed saponin A inhibits oxidative stress and thus inhibits allergic airway inflammation, then pokeweed saponin A, as a potential antioxidant, also has a certain alleviating effect on other oxidative stress-related diseases. |
| biological activity | Esculentoside A (EsA), a triterpene saponin isolated from the root of pokeweed Phytolacca esculenta. Esculentoside A (EsA) has anti-inflammatory activity and selective inhibitory activity on cyclooxygenase -2 (COX-2). Esculentoside A (EsA) inhibits inflammatory response in LPS-induced acute lung injury (ALI) by inhibiting (NF-KB) and mitogen-activated protein kinase (MAPK) signaling pathways. |
| in vitro study | Esculentoside A (0-10μM; 24 hours) reduced the release of TNF concentration in primed macrophages . |
| in vivo study | Esculentoside A (EsA) (intraperitoneal injection; 20 mg/kg; once a day; 4 weeks) plays significant roles in the treatment of BXSB mice through modulation of inflammatory cytokines, inhibition of renal cell proliferation and induction of apoptosis . Esculentoside A (EsA) (injected intraperitoneally; 5, 10 and 20 mg/kg; once a day; 7 days) dose-dependently decreases the TNF, IL-1 and IL-6 levels in the sera of mice following LPS challenge. Animal Model: BXSB mice Dosage: 20 mg/kg Administration: Intraperitoneal injection; 20 mg/kg; once a day; 4 weeks Result: Alleviated the renal damage of LN. |
| Animal Model: | BXSB mice |
| Dosage: | 20 mg/kg |
| Administration: | Intraperitoneal injection; 20 mg/kg; once a day; 4 weeks |
| Result: | Alleviated the renaldamageof ln. |
| chemical properties | white crystalline powder, soluble in water, hot methanol, ethanol, n-butanol, insoluble in lipophilic solvents such as acetone and ether, and comes from the commercial land Phytolacca acinosa Roxb. |
| use | pokeweed saponin a has anti-inflammatory, immune and anti-tumor effects. used for content determination/identification/pharmacological experiment, etc. |
Last Update：2024-04-09 21:31:57
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Product Name: Esculentoside A Request for quotation
CAS: 65497-07-6
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
CAS: 65497-07-6
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Multiple SpecificationsSpot supply
Product Name: Esculentoside A Visit Supplier Webpage Request for quotationCAS: 65497-07-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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