656247-17-5
Nintedanib
CAS: 656247-17-5
Molecular Formula: C31H33N5O4
656247-17-5 - Names and Identifiers
| Name | Nintedanib |
| Synonyms | 100837 BIBF 1120 VARGATEF INTEDANIB Nintedanib Nintedanib-016 INTEDANIB BASE Intedanib Vargatef Intedanib Vargatef Nintedanib (BIBF 1120) |
| CAS | 656247-17-5 |
| EINECS | 1592732-453-0 |
656247-17-5 - Physico-chemical Properties
| Molecular Formula | C31H33N5O4 |
| Molar Mass | 539.64 |
| Density | 1.284±0.06 g/cm3(Predicted) |
| Melting Point | >237oC (dec.) |
| Boling Point | 742.2±60.0 °C(Predicted) |
| Solubility | DMSO 6 mg/mL Water <1 mg/mL Ethanol 3 mg/mL |
| Appearance | Form Yellow solid, color Light Yellow to Light Green |
| Color | Light Yellow to Light Green |
| pKa | 11.06±0.20(Predicted) |
| Storage Condition | Refrigerator |
| Use | BIBF1120 is a potent kinase inhibitor found to affect VEGF, PDGF, and FGF receptors. |
| In vitro study | BIBF1120 has little inhibitory effect on tyrosine kinase receptors such as EGFR, HER2, InsR, IGF1R or cell cycle kinases CDK1, CDK2 and CDK4, and IC50 is greater than 1x10 |
| In vivo study | Treatment of 100mg BIBF 1120 per kg of mouse body weight in Fadu xenografts showed a 76% reduction in tumor vessel density. BIBF1120 also had significant inhibitory effects on transplanted tumor models Caki-1, HT-29, SKOV-3, Calu6 and PAC-120. BIBF 1120 has been used to treat a variety of cancers including non-small cell lung cancer, prostate cancer, ovarian cancer, and colorectal cancer. BIBF 1120 is currently in Phase II clinical trials. |
656247-17-5 - Upstream Downstream Industry
656247-17-5 - Reference
| Reference Show more | 1. [IF=7.79] Xin Chang et al."Nanoengineered immunosuppressive therapeutics modulating M1/M2 macrophages into the balanced status for enhanced idiopathic pulmonary fibrosis therapy."Nanoscale. 2020 Apr;12(16):8664-8678 2. [IF=4.36] Zhenghua Wu et al."Schisandrol A, the main active ingredient of Schisandrae Chinensis Fructus, inhibits pulmonary fibrosis through suppression of the TGF-β signaling pathway as revealed by UPLC-Q-TOF/MS, network pharmacology and experimental verification. |
656247-17-5 - Introduction
Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor with inhibitory effects on VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.
Last Update：2022-10-16 17:30:55
656247-17-5 - Nature
| Solubility | DMSO (Slightly), Methanol (Slightly) |
Last Update：2024-04-10 22:29:15
656247-17-5 - Introduction
Nintedanib is a chemical substance with the formula C5H4N4O2. The following is a description of some of the properties, uses, methods and safety information of Nintedanib:
Nature:
1. Appearance: Nintedanib is usually white crystalline powder.
2. Melting Point: about 295-299 degrees Celsius.
3. Solubility: Nintedanib can be slightly soluble in water, and more soluble in organic solvents such as ethanol and acetone.
Use:
1. Ultraviolet absorber: Nintedanib has the characteristics of absorbing ultraviolet light, commonly used as ultraviolet absorber, is widely used in sunscreen, cosmetics and drugs.
2. Dye: Nintedanib can also be used as a dye, commonly used in fabrics, plastics and other fields.
Preparation Method:
Nintedanib can be prepared by a variety of different synthesis methods. One of the commonly used methods is to react 2,4, 6-triaminopyrrole with dimethyl carbonate anhydride, after a series of reaction and purification steps, Nintedanib was finally obtained.
Safety Information:
1. Nintedanib is generally safe under normal use, but if you have an allergic reaction or discomfort, you should stop using it immediately and consult a doctor.
2. Nintedanib should be kept away from fire sources and avoid contact with oxidants.
3. When using Nintedanib, you should wear appropriate protective equipment, such as gloves and goggles, to prevent direct contact and inhalation.
4. If you accidentally inhale or touch Nintedanib, you should immediately rinse with water, or follow the correct first aid measures, if necessary, please seek medical help.
Please note that the above information is for reference only. When using Nintedanib or conducting any chemical experiments, please be sure to follow the correct operating procedures and safety measures, and follow the relevant laws and regulations. If necessary, please consult a professional or relevant organization.
Nature:
1. Appearance: Nintedanib is usually white crystalline powder.
2. Melting Point: about 295-299 degrees Celsius.
3. Solubility: Nintedanib can be slightly soluble in water, and more soluble in organic solvents such as ethanol and acetone.
Use:
1. Ultraviolet absorber: Nintedanib has the characteristics of absorbing ultraviolet light, commonly used as ultraviolet absorber, is widely used in sunscreen, cosmetics and drugs.
2. Dye: Nintedanib can also be used as a dye, commonly used in fabrics, plastics and other fields.
Preparation Method:
Nintedanib can be prepared by a variety of different synthesis methods. One of the commonly used methods is to react 2,4, 6-triaminopyrrole with dimethyl carbonate anhydride, after a series of reaction and purification steps, Nintedanib was finally obtained.
Safety Information:
1. Nintedanib is generally safe under normal use, but if you have an allergic reaction or discomfort, you should stop using it immediately and consult a doctor.
2. Nintedanib should be kept away from fire sources and avoid contact with oxidants.
3. When using Nintedanib, you should wear appropriate protective equipment, such as gloves and goggles, to prevent direct contact and inhalation.
4. If you accidentally inhale or touch Nintedanib, you should immediately rinse with water, or follow the correct first aid measures, if necessary, please seek medical help.
Please note that the above information is for reference only. When using Nintedanib or conducting any chemical experiments, please be sure to follow the correct operating procedures and safety measures, and follow the relevant laws and regulations. If necessary, please consult a professional or relevant organization.
Last Update：2024-04-09 19:05:02
Supplier List
Multiple Specifications
Product Name: Nintedanib Hydrochloride Request for quotationCAS: 656247-17-5(free base)
Tel: 0714-3999186
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Product Name: Nintedanib (BIBF 1120) Visit Supplier Webpage Request for quotationCAS: 656247-17-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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Multiple Specifications
Product Name: Nintedanib Hydrochloride Request for quotationCAS: 656247-17-5(free base)
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Nintedanib (BIBF 1120) Visit Supplier Webpage Request for quotationCAS: 656247-17-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History
Raw Materials for 656247-17-5
N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide
(E)-Methyl 1-acetyl-3-(Methoxy(phenyl)Methylene)-2-oxoindoline-6-carboxylate
Nintedanib Ethanesulfonate Salt
2,3-Dihydro-3-(MethoxyphenylMethylene)-2-oxo-1H-indole-6-carboxylic acid Methyl ester
1-Acetyl-3-(ethoxyphenylmethylene)-2,3-dihydro-2-oxo-1H-indole-6-carboxylic acid methyl ester
(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester
Nintedanib Impurity 15
(E)-Methyl 1-acetyl-3-(Methoxy(phenyl)Methylene)-2-oxoindoline-6-carboxylate
Nintedanib Ethanesulfonate Salt
2,3-Dihydro-3-(MethoxyphenylMethylene)-2-oxo-1H-indole-6-carboxylic acid Methyl ester
1-Acetyl-3-(ethoxyphenylmethylene)-2,3-dihydro-2-oxo-1H-indole-6-carboxylic acid methyl ester
(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester
Nintedanib Impurity 15