65664-81-5

65664-81-5 - Names and Identifiers

Name	4,4'-dianilino-1,1'-binaphthyl-5,5'-di-sulfonic A
Synonyms	BIS-ANS BIS-ANS DIPOTASSIUM SALT 8-Anilino-1-naphthalenesulfonic Acid Di 4,4'-dianilino-1,1'-binaphthyl-5,5'-di-sulfonic A 4,4'-Bis(1-anilinonaphthalene-8-sulfonic Acid) DipotassiuM Salt BIS-(5,5')-8-ANILINO-1-NAPHTHALENE SULFONIC ACID DIPOTASSIUM SALT 4,4'-DIANILINO-1,1'-BINAPHTHYL-5,5'-DISULFONIC ACID, POTASSIUM SALT 4,4'-DIANILINO-1,1'-BINAPHTHYL-5,5'-DISULFONIC ACID DIPOTASSIUM SALT 4,4'-Bis(phenylaMino)-[1,1'-binaphthalene]-5,5'-disulfonic Acid PotassiuM Salt
CAS	65664-81-5
InChI	InChI=1/C32H24N2O6S2.2K/c35-41(36,37)29-15-7-13-25-23(17-19-27(31(25)29)33-21-9-3-1-4-10-21)24-18-20-28(34-22-11-5-2-6-12-22)32-26(24)14-8-16-30(32)42(38,39)40;;/h1-20,33-34H,(H,35,36,37)(H,38,39,40);;/q;2*+1/p-2

65664-81-5 - Physico-chemical Properties

Molecular Formula	C32H22K2N2O6S2
Molar Mass	672.85
Color	light yellow
BRN	5714637
In vitro study	Bis-ANS is a fluorescent molecule that has been used to probe exposed hydrophobic patches in proteins and to monitor the formation of protein aggregates. Bis-ANS is a bivalent naphthalene sulfonate with aniline moieties. Bis-ANS modulates the liquid-liquid phase separation of TDP-43 low complexity domain (LCD).

65664-81-5 - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
WGK Germany	3
FLUKA BRAND F CODES	3-10

65664-81-5 - Reference Information

biological activity

Bis-ANS dipitasite is a protein fluorescent probe that binds Bis-ANS to tubulin with a Kd of 2 μm. Bis-ANS dipotassium is an effective biphasic regulator of protein liquid-liquid phase separations (LLPS). Low concentration of Bis-ANS dipotassium promoted LLPS, and high concentration inhibited LLPS.

Last Update：2024-04-09 20:52:54

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