66575-29-9
Forskolin
CAS: 66575-29-9
Molecular Formula: C22H34O7
66575-29-9 - Names and Identifiers
66575-29-9 - Physico-chemical Properties
| Molecular Formula | C22H34O7 |
| Molar Mass | 410.5 |
| Density | 1.23 |
| Melting Point | 282-232 °C |
| Boling Point | 520℃ |
| Specific Rotation(α) | D25 -26.19° (c = 1.68 in CHCl3) |
| Flash Point | 172℃ |
| Water Solubility | Soluble in ethanol, dimethylsulfoxide and chloroform. Insolule in water. |
| Solubility | Soluble in methanol, DMSO |
| Appearance | White powder |
| Color | off-white |
| Maximum wavelength(λmax) | ['305nm(lit.)'] |
| Merck | 14,2476 |
| BRN | 1692716 |
| pKa | 11.00±0.70(Predicted) |
| Storage Condition | room temp |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 4 months. |
| Refractive Index | 1.5300 (estimate) |
| MDL | MFCD00082317 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Coleus forskohlii. |
| In vitro study | Forskolin can make the content of cAMP in membrane, cell or tissue preparation liquid rise. Forskolin not only activates AC but also interacts with certain other proteins, including glucose transporters and ion channels. Forskolin can promote the activation of 9 different independent AC forms, although the efficiency of AC9 is a bit low, which can be used to provide an identification and quantification of G protein (G s) methods for high affinity binding sites for the-AC complex. G protein-coupled receptor activation G protein contributes to Forskolin-stimulated cAMP production in cells because G protein-Forskolin has a potentiating effect on AC activity. Forskolin stimulates adenylate cyclase activity without interacting with cell surface receptors. In adipocytes, Forskolin's promotes the production of cAMP, which in turn can inhibit the degranulation of basophils and mast cells and the release of histamine, reduce blood pressure and intraocular pressure, inhibit platelet aggregation, and promote vasodilation, bronchiectasis and thyroid hormone secretion, stimulate lipolysis. Forskolin inhibits the binding of platelet activating factor (PAF), which is independent of cAMP formation. This inhibition may be achieved by Forskolin's acting directly on PAF or by interfering with the binding of PAF to its receptor. Forskolin also appears to have an effect on a variety of membrane transport proteins and can inhibit glucose transport in adipocytes, erythrocytes, platelets, and other cells. Forskolin is also used to treat glaucoma. |
66575-29-9 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 21 - Harmful in contact with skin |
| Safety Description | S22 - Do not breathe dust. S36/37 - Wear suitable protective clothing and gloves. |
| WGK Germany | 3 |
| RTECS | QL6150000 |
| FLUKA BRAND F CODES | 10-21 |
| HS Code | 29329990 |
66575-29-9 - Reference Information
| pharmacological effects | fosskolin, also known as the "second messenger", is widely distributed in various tissues of the body, affect many aspects of cell activity, with the promotion of fat, glycogen decomposition, myocardial contraction, smooth muscle relaxation and inhibition of platelet aggregation. According to reports in the literature, FSK and its analogs are rhodanane-type Diterpenoids, both are direct agonists of adenylate cyclase, which do not pass through the receptor nor inhibit phosphodiesterase, instead, a direct increase in intracellular concentration results in physiological activity. It has been proved by pharmacological studies that fosskolin is the only strongest activator of adenylate cyclase that is obtained from plants, increase the concentration of cyclic adenylate in cells of various tissues, thus participating in the regulation of various cell functions and playing a wide regulatory role in vivo. The main function of FSK is to lower blood pressure, relieve pain, dilate bronchioles, dilate blood vessels and strengthen heart. The active ingredient FSK has important medical effects, including lowering blood pressure, relaxing smooth muscle, increasing the release of thyroid hormones, promoting the secretion of the digestive tract, reducing intraocular pressure. India for digestive system diseases, such as driving, to flatulence, cure Abdominal Pain for circulatory system diseases, treatment of congestive heart failure, coronary artery blood flow deficiency, improve brain blood circulation, have pain relief effect, treatment of asthma, tracheitis. At present, fosskoline is clinically used for the treatment of cardiovascular diseases, glaucoma, bronchial asthma, etc. At the same time, it can also regulate various tissues by activating adenylate cyclase, and is an activator of other drugs. |
| biological activity | Colforsin (Forskolin, coolol, Colforsin) in a variety of cell types, it is a ubiquitous activator of eukaryotic adenylate cyclase (AC) and is commonly used to increase cAMP levels in cell physiology studies. Forskolin can also stimulate the activity of PXR and FXR to induce autophagy. |
| Target | Value |
| Use | fosskolin has the effect of lowering intraocular pressure. for content determination/identification/pharmacological experiments and other pharmacological effects: with anti-hypertension, anti-tumor metastasis and anti-glaucoma and other pharmacological activities |
| category | toxic substances |
| toxicity grade | poisoning |
| Acute toxicity | oral-rat LD50 2550 mg/kg; Oral-mouse LD50: 2300 mg/kg |
| flammability hazard characteristics | flammable, spicy and irritating smoke |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; It is stored and transported separately from strong acid, strong alkali and food |
| fire extinguishing agent | Sand, carbon dioxide, foam, water mist |
Last Update：2024-04-10 22:29:15
Supplier List
Spot supply
Product Name: Forskolin Visit Supplier Webpage Request for quotationCAS: 66575-29-9
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Multiple SpecificationsSpot supply
Product Name: Forskolin Visit Supplier Webpage Request for quotationCAS: 66575-29-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Forskolin Visit Supplier Webpage Request for quotationCAS: 66575-29-9
Tel: +86-(0)731-84213302
Email: sales@staherb.cn
Mobile: +86 13875855783
QQ: 484702402
WhatsApp: +86 18374838656
Linkedin: +86 18374838656
Spot supply
Product Name: Forskolin Visit Supplier Webpage Request for quotationCAS: 66575-29-9
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Multiple SpecificationsSpot supply
Product Name: Forskolin Visit Supplier Webpage Request for quotationCAS: 66575-29-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Forskolin Visit Supplier Webpage Request for quotationCAS: 66575-29-9
Tel: +86-(0)731-84213302
Email: sales@staherb.cn
Mobile: +86 13875855783
QQ: 484702402
WhatsApp: +86 18374838656
Linkedin: +86 18374838656
View History