675602-92-3

675602-92-3 - Names and Identifiers

Name	2,3,6-Trifluoropyridine-4-carboxylic acid
Synonyms	2,3,6-TRIFLUOROISONICOTINIC ACID 2,3,6-TRIFLUOROPYRIDINE-4-CARBOXYLIC ACID 2,3,6-trifluoro-4-pyridinecarboxylic acid 2,3,6-Trifluoropyridine-4-carboxylic acid 4-Pyridinecarboxylic acid, 2,3,6-trifluoro-
CAS	675602-92-3
InChI	InChI=1/C6H2F3NO2/c7-3-1-2(6(11)12)4(8)5(9)10-3/h1H,(H,11,12)

675602-92-3 - Physico-chemical Properties

Molecular Formula	C6H2F3NO2
Molar Mass	177.08
Density	1.642±0.06 g/cm3(Predicted)
Melting Point	115-121°C
Boling Point	377.8±37.0 °C(Predicted)
Flash Point	182.3°C
Vapor Presure	2.22E-06mmHg at 25°C
pKa	1.76±0.10(Predicted)
Storage Condition	Room Temprature
Refractive Index	1.491
MDL	MFCD03840204

675602-92-3 - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
WGK Germany	3
Hazard Class	IRRITANT

675602-92-3 - Introduction

2,3, acid is an organic compound with the chemical formula C6H2F3NO2. The following is an introduction to some of its properties, uses, methods and safety information:

Nature:
-Appearance: colorless to light yellow crystal;
-Melting point: 108-110 degrees Celsius;
-Boiling point: 315-317 degrees Celsius;
-Solubility: easy to dissolve in organic solvents, such as alcohols and ketones;
-Stability: Stable at room temperature, but may react when encountering strong oxidants.

Use:
2,3, acid has certain uses in organic synthesis, such:
-as a drug intermediate: can be used to produce some drugs, such as anticoagulants, anti-cancer drugs, etc;
-for catalytic reaction: can be used as a catalyst or ligand to participate in some organic synthesis reactions, such as amination reaction, aromatization reaction.

Preparation Method:
2,3, acid: usually synthesized by the following methods:
-Fluorination of pyridine: reacting pyridine with fluorine gas through a series of reaction steps, fluorinating pyridine to obtain 2,3, 6-trifluoropyridine;
-Carboxylation reaction: 2,3, 6-trifluoropyridine is reacted with chlorinated alkane or oxidant, and carboxylated through a series of reaction steps to obtain 2,3, 4-acid.

Safety Information:
- 2,3, acid may be irritating to eyes, skin and respiratory tract, please pay attention to protective measures;
-Avoid inhalation, ingestion or contact with skin during use;
-Avoid contact with oxidants and strong acids during storage;
-Follow chemical safety practices during handling and storage.

Last Update：2024-04-09 15:17:59