6837-93-0
NSC16168
CAS: 6837-93-0
Molecular Formula: C17H15NO9S3
6837-93-0 - Names and Identifiers
6837-93-0 - Physico-chemical Properties
| Molecular Formula | C17H15NO9S3 |
| Molar Mass | 473.5 |
| Density | 1.5197 (rough estimate) |
| pKa | -1.16±0.40(Predicted) |
| Storage Condition | 2-8°C，干燥，密封 |
| Refractive Index | 1.7000 (estimate) |
6837-93-0 - Reference Information
| biological activity | NSC16168 is a ERCC1-XPF specific inhibitor with an IC50 value of 0.42 μm. NSC16168 can inhibit DNA repair and enhance the efficacy of CDDP in cancer. |
| Target | IC50: 0.42 μm (ERCC1-XPF). |
| Cell Line: | H460 cells. |
| Concentration: | 0-50 μM. |
| Incubation Time: | 2 h. |
| Result: | Potentiated cisplatin efficacy in cancer cells. The tumor growth was minimally affected by compound and the mice displayed no signs of distress or toxic side effects. The combination treatment with 16168 and cisplatin inhibited H460 tumor growth, which was maintained for the duration of the compound injections. |
| Animal Model: | 2.5×10 6 H460 cells were injected s.c. in the right flank of each mouse. |
| Dosage: | 20 mg/kg. |
| Administration: | IP, twice daily for 10 days. |
| category | toxic substances |
| toxicity grade | low toxicity |
| Acute toxicity | oral-rat LD50: 11500 mg/kg |
| stimulation data | eyes-rabbit 100 mg/24 h severe |
| flammability hazard characteristics | flammability; Toxic nitrogen oxide and sulfur oxide fumes from combustion |
| storage and transportation characteristics | warehouse ventilation and low temperature drying |
| extinguishing agent | dry powder, foam, sand, carbon dioxide, water mist |
Last Update：2024-04-09 20:49:11
