69321-60-4

Name	2,6-Dibromotoluene
Synonyms	2,6-Dibromotoluene 2,6-DIBROMOTOLUENE 2,6-Second Bromotoluene 1,3-Dibromo-2-methylbenzene 1,3-dibromo-2-methylbenzene Benzene, 1,3-dibromo-2-methyl-
CAS	69321-60-4
EINECS	250-689-9
InChI	InChI=1/C7H6Br2/c1-5-6(8)3-2-4-7(5)9/h2-4H,1H3

Molecular Formula	C7H6Br2
Molar Mass	249.93
Density	1,812 g/cm3
Melting Point	2-6°C
Boling Point	112-113°C 7mm
Flash Point	112-113°C/7mm
Vapor Presure	0.0436mmHg at 25°C
Appearance	White solid
BRN	3235502
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.6060
MDL	MFCD00013524

Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R36/38 - Irritating to eyes and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S37 - Wear suitable gloves.
HS Code	29039990

NIST chemical information	information provided by: webbook.nist.gov (external link)
Application	2, 6-dibromobenzyl is an important pharmaceutical intermediate, leukotrienes and prostaglandins are important mediators of inflammation, which can promote the development of inflammation in different ways. Patent WO2006128142A2 uses 2, 6-dibromobenzyl bromide as raw material to synthesize cytosolic phospholipase (cPLA2) it can be used as a chemical inhibitor of leukotriene and prostaglandin activity to achieve the effect of treating inflammation.
preparation	1, 3-dibromo-2-methylbenzene: (3, A solution of 5-dibromo-4-methylphenyl) amine in water (80mL) and concentrated HCl(7.5mL) was stirred for 20 min, the mixture was then cooled and a solution of NaNO2(3.4g / 40mL H2O) was added at 0-5 °c. The reaction mixture was stirred at 0-5 °c for 2 hours, then the suspension was added to a solution of hypophosphorous acid (50%,27.9g) and the mixture was cooled to 0 °c. The mixture was stirred at room temperature overnight. It was then extracted with CH2Cl2(100ml x 2). The organic layer was washed with brine (30ml) and dried over Na2SO4. After silica column chromatography (eluting with petroleum ether), 3.57G of product were obtained as a colorless liquid. 1, 3-dibromo-2-methylbenzene, yield 3.57g.

Last Update：2024-04-09 15:16:52

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69321-60-4

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