Name | D-Phenylalanine, N-[6-[4-(phenylmethoxy)phenyl]-4-pyrimidinyl]- |
Synonyms | BAY 73-1449 D-Phenylalanine, N-[6-[4-(phenylmethoxy)phenyl]-4-pyrimidinyl]- |
CAS | 693790-96-4 |
Molecular Formula | C26H23N3O3 |
Molar Mass | 425.48 |
Density | 1.273±0.06 g/cm3(Predicted) |
Boling Point | 700.4±60.0 °C(Predicted) |
pKa | 3.35±0.10(Predicted) |
In vivo study | BAY 73-1449 (0.1-1 mg/kg; i.v.) does not significantly reduce mesenteric inflow, but significantly reduces splenic shunt vessel outflow in rats. BAY 73-1449 (1-5 mg/kg, s.c. once daily for 7 d) has no effects on the degree of porto-systemic shunting in rats. BAY 73-1449 (1 mg/kg, s.c. once daily for 7 d), has no effects on portal pressures in rats. Animal Model: Male Wistar rats (250-350 g) are ligated portal vein Dosage: 0.1, 1 mg/kg Administration: A single i.v. Result: Significantly reduced shunt flow without affecting mesenteric flow. |
biological activity | BAY 73-1449 is an antagonist of selective prostacyclin receptor (prostacyclin receptor, IP), which is used in human HEL cells and rat DRG. The cAMP analysis has a high titer (IC50 value less than 0.1 nM). BAY 73-1449 can be used for the study of lowering blood pressure. |
target | IP Receptor <0.1 nM (IC 50 ) |
in vivo study | BAY 73-1449 (0.1-1 mg/kg; I. v.) does not significantly reduce mesenteric flow, but significantly reduces splenic shunvessel outflow in rats. BAY 73-1449 (1-5 mg/kg, S. c. once daily for 7 d) has no effects on the degree of porto-systemic shunting in rats. BAY 73-1449 (1 mg/kg, s.c. once daily for 7 d), has no effects on portal pressures in rats. Animal Model: Male Wistar Rats (250-350g) are ligated portal vein Dosage: 0.1, 1 mg/kg Administration: A single I. v. Result: significantly reduced shoot flow without affecting mesenteric flow. |
Animal Model: | Male Wistar rats (250-350 g) are ligated portal vein |
Dosage: | 0.1, 1 mg/kg |
Administration: | A single i.v. |
Result: | Significantly reduced shunt flow without affecting mesenteric flow. |