6964-62-1

Name	NSC 66811
Synonyms	Nsc66811 NSC66811 NSC 66811 NSC-66811 7-(alpha-Anilinobenzyl)-2-methyl-8-quinolinol 7-[anilino(phenyl)methyl]-2-methylquinolin-8-ol 2-Methyl-7-(phenyl(phenylamino)methyl)quinolin-8-ol 2-Methyl-7-[Phenyl(phenylamino)methyl]-8-quinolinol 8-Quinolinol,2-methyl-7-[phenyl(phenylamino)methyl]- 8-Hydroxy-2-methyl-7-[phenyl(phenylamino)methyl]quinoline
CAS	6964-62-1

Molecular Formula	C23H20N2O
Molar Mass	340.42
Density	1.235±0.06 g/cm3(Predicted)
Melting Point	143.0 to 147.0 °C
Boling Point	529.5±45.0 °C(Predicted)
Solubility	Soluble in DMSO (up to 25 mg/ml).
Appearance	solid
Color	White
Maximum wavelength(λmax)	['250nm(EtOH)(lit.)']
pKa	4.42±0.50(Predicted)
Storage Condition	Keep in dark place,Inert atmosphere,2-8°C
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

biological activity	NSC 66811 is a MDM2-p53 inhibitor with a Ki value of 120 nM bound to MDM2.
Cell Line:	HCT-116 (p53 +/+ and p53 -/- ) cells [1] .
Concentration:	0, 5, 10, 20 μM.
Incubation Time:	48 h.
Result:	Dose-dependently induced the accumulation of p53, MDM2, and p21 cip1/waf proteins in the HCT-116 human colon cancer cell line with wild-type p53. Had no effect on the levels for p53, MDM2, and p21 cip1/waf protein in the isogenic HCT-116 p53 -/- cell line.

Last Update：2024-04-09 20:49:11

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CAS: 6964-62-1
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6964-62-1

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