698-29-3
4-amino-2-methylpyrimidine-5-carbonitrile
CAS: 698-29-3
Molecular Formula: C6H6N4
698-29-3 - Names and Identifiers
| Name | 4-amino-2-methylpyrimidine-5-carbonitrile |
| Synonyms | NSC 459 Pynitrile 4-Amino-5-cyano-2-methylpyrimidine 5-Cyano-4-aMino-2-MethylpyriMidine 4-amino-2-methylpyrimidine-5-carbonitrile 2-Methyl-4-aminopyrimidine-5-carbonitrile 5-Pyrimidinecarbonitrile, 4-amino-2-methyl- (6CI,7CI,8CI,9CI) |
| CAS | 698-29-3 |
| EINECS | 211-814-2 |
| InChI | InChI=1/C6H6N4/c1-4-9-3-5(2-7)6(8)10-4/h3H,1H3,(H2,8,9,10) |
698-29-3 - Physico-chemical Properties
| Molecular Formula | C6H6N4 |
| Molar Mass | 134.14 |
| Density | 1.27±0.1 g/cm3(Predicted) |
| Melting Point | 249℃ |
| Boling Point | 315.6±27.0 °C(Predicted) |
| Water Solubility | Slightly soluble in water (6.4 g/L at 25°C). Soluble in dimethyl sulfoxide, ethanol and methanol. |
| Appearance | Shape Powder, color Pale yellow |
| pKa | 3.00±0.10(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,2-8°C |
| Use | Introduction 2-methyl -4-amino pyrimidine -5-nitrile, Chinese alias: 4-amino -5-cyano -2-methyl pyrimidine, this product is a gray-yellow crystalline solid, is an organic intermediate. It has been reported that 2-methyl-4-aminopyrimidin-5-nitrile can be used to prepare steroidal anti-androgen compounds. Pharmacological experiments have proved that these compounds have good anti-prostate cancer activity. |
698-29-3 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S36/37 - Wear suitable protective clothing and gloves. |
698-29-3 - Upstream Downstream Industry
698-29-3 - Security information
| Hazard Note | Irritant |
| Hazard Level | 6.1 |
Last Update：2024-04-10 22:29:15
698-29-3 - Preparation
add 5kg of water and 5kg of ethanol to a clean 20L reaction bottle and stir evenly. Take 1.8kg of solid sodium hydroxide and add it into the system and stir for 30min until it is completely dissolved. The ice bath is cooled to below 25 degrees, and 3.2kg of acetamidine hydrochloride is added. It is basically not exothermic and is white turbid. After adding, stir for 10min. The ethanol solution of dicyanoacetate is added dropwise, the initial heat release is added dropwise, the temperature is kept below 30 ℃, and the back is basically not exothermic, which can accelerate the droplet acceleration. After dropping, the temperature is raised to 65-70 ℃ for 1.5h. The reaction solution is slowly poured into 10kg of ice water while it is hot and stirred for 20min. The treatment liquid centrifuge was centrifuged to obtain 4.6kg of wet product. Drying at 70-75 ℃ to constant weight. 3.6kg of white-like solid was obtained, the liquid phase was 98.2%, and the yield was 85.7%.
Last Update：2024-04-10 22:29:15
698-29-3 - Nature
| Solubility | DMSO, Ethanol, Methanol |
Last Update：2024-04-09 21:04:16
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Product Name: 4-Amino-2-Methylpyrimidine-5-Carbonitrile Visit Supplier Webpage Request for quotation
CAS: 698-29-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 698-29-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History
Raw Materials for 698-29-3
Sodium
Acetamidine hydrochloride
Ethoxymethylenemalononitrile
5-Pyrimidinecarbonitrile, 6-amino-1,4-dihydro-2-methyl-
Acetamidine Base
Acetamidine hydrochloride
Ethoxymethylenemalononitrile
5-Pyrimidinecarbonitrile, 6-amino-1,4-dihydro-2-methyl-
Acetamidine Base
Downstream Products for 698-29-3