6R-BH4
Tetrahydrobiopterin
CAS: 17528-72-2
Molecular Formula: C9H15N5O3
6R-BH4 - Names and Identifiers
6R-BH4 - Physico-chemical Properties
| Molecular Formula | C9H15N5O3 |
| Molar Mass | 241.25 |
| Density | 1.89±0.1 g/cm3(Predicted) |
| Melting Point | >202°C (dec.) |
| Boling Point | 506.6±60.0 °C(Predicted) |
| Solubility | Aqueous Acid (Slightly), DMSO (Slightly), Water (Slightly) |
| Appearance | Solid |
| Color | White to Off-White |
| pKa | 14.22±0.20(Predicted) |
| Storage Condition | -20°C |
| Stability | Hygroscopic |
| In vitro study | MicMicroglial cell cultures under hyperoxia are supplemented or not with an effective dose of Tetrahydrobiopterin (BH4) (100 μM). Exposure of microglial cells to hyperoxia-induced oxidative stress for 24 h reveals a robust increase in TSP-1 mRNA expression and protein compare to normoxia (21% O 2 ). Tetrahydrobiopterin supplementation significantly prevents hyperoxia-induced microglial activation by diminishing Iba-1 and TSP-1 expression and prevents microvascular injury in choroidal explants. |
| In vivo study | To assess the levels of Tetrahydrobiopterin in the retina, three to five pools of retinas are collected from WT and hph-1mice at postnatal age 7, 14, and 22 and evaluated by LC-MS/MS. LC-MS/MS analysis confirm a significant decrease by approximately 90% in the concentration levels of Tetrahydrobiopterin in retinal tissue from hph-1 mice (0.0009±0.0006; p<0.0001, 0.01±0.001; p<0.0001 and 2.45±0.40; p<0.005) compare to the WT group (0.014±0.001, 0.092±0.01, and 23.13±6.44) at P7, P14, and P22, respectively. |
6R-BH4 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
6R-BH4 - Reference
| Reference Show more | 1. [IF=5.81] Yan Tao et al."Ligustilide Prevents Radiation Enteritis by Targeting Gch1/BH4/eNOS to Improve Intestinal Ischemia."Front Pharmacol. 2021 Apr;0:893 |
6R-BH4 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.183 ml | 15.915 ml | 31.83 ml |
| 5 mM | 0.637 ml | 3.183 ml | 6.366 ml |
| 10 mM | 0.318 ml | 1.592 ml | 3.183 ml |
| 5 mM | 0.064 ml | 0.318 ml | 0.637 ml |
Last Update：2024-01-02 23:10:35
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Mobile: 18021002903
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