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7-Azaindole

7-Azaindole

CAS: 271-63-6

Molecular Formula: C7H6N2

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7-Azaindole - Names and Identifiers

Name 7-Azaindole
Synonyms AZI
7-Azaindole
7-Aza-7H-indole
1,7-diazaindene
7-Aza-1-pyrindine
1,7-Diaza-1H-indene
Pyrrolo(2,3-b)pyridine
7-AZAINDOLE CRYSTALLINE
1H-Pyrrolo[2,3-b]pyridine
7H-Pyrrolo[2,3-b]pyridine
1H-pyrrolo(2,3-b)pyridine
CAS 271-63-6
EINECS 205-981-0
InChI InChI=1/C7H6N2/c1-2-6-3-5-9-7(6)8-4-1/h1-5H,(H,8,9)
InChIKey MVXVYAKCVDQRLW-UHFFFAOYSA-N

7-Azaindole - Physico-chemical Properties

Molecular FormulaC7H6N2
Molar Mass118.14
Density1.1151 (rough estimate)
Melting Point105-107 °C (lit.)
Boling Point270 °C (753.1004 mmHg)
Flash Point270°C
Solubility Chloroform, Methanol
Vapor Presure0.0094mmHg at 25°C
AppearanceBrown transparent solid
ColorWhite to off-white
BRN109667
pKa7.69±0.20(Predicted)
Storage ConditionSealed in dry,Room Temperature
Refractive Index1.5500 (estimate)
MDLMFCD00005606
Physical and Chemical Properties
melting point 103-107°C
boiling point 270°C
UseUsed as a reagent for organic synthesis

7-Azaindole - Risk and Safety

Risk CodesR36 - Irritating to the eyes
R41 - Risk of serious damage to eyes
R37/38 - Irritating to respiratory system and skin.
R22 - Harmful if swallowed
Safety DescriptionS39 - Wear eye / face protection.
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
WGK Germany3
RTECSUY8710000
HS Code29339990
Hazard ClassIRRITANT

7-Azaindole - Reference Information

NIST chemical information Information provided by: webbook.nist.gov (external link)
EPA chemical information Information provided by: ofmpub.epa.gov (external link)
overview 7-azafindole is an important heterocyclic intermediate with good biological and medicinal value. it is the core structure of many drugs, such as antineoplastic drugs, dopamine D4 receptor, p38 kinase inhibitor, thrombin inhibitor, etc., so it has a wide range of application value in medical research.
application 7-azafindole is a heterocyclic organic compound, which is an organic synthesis intermediate and a pharmaceutical intermediate, and can be used in laboratory research and development processes and chemical and pharmaceutical synthesis processes.
synthesis method in a single-mouthed bottle, 2.0g 2-amino -3-methylpyridine and 2.5g N-methylformaniline are added to 40mL dichloromethane, and 3.15g PCl is added by stirring in an ice water bath. After 4 hours of reaction, the reaction system was slowly poured into 40mL ammonia water, and the insoluble matter was removed by suction filtration. The organic layer is separated, the organic layer is washed twice, anhydrous sodium sulfate is dried, evaporated to obtain light yellow solid 2.91g, and the yield is 70%. 1HNMR(500MHz,CDCl3)δ8.91(s,1H),8.16(d,J = 3.9Hz,1H),7.46(d,J = 7.2Hz,1H),7.39(t,J = 7.9Hz,2H),7.27(d,J = 7.9Hz,2H),7.17(t,J = 7.4Hz,1H),6.89-6.91(m,1H),3.59(s,3H),2.39(s,3H). In a three-mouth bottle, under the protection of nitrogen, 5gN-methyl-N-phenyl-N'-(2-(3-methylpyridine) group) formamidine was dissolved in 30mL of dry tetrahydrofuran and lowered to -20 ℃. Then slowly drip in 13mL n-butyl lithium (2.5M), after 5 hours of reaction, the reaction system is poured into 1M citric acid aqueous solution to quench the reaction. Extracting with ethyl acetate, the organic layer is separated, the water layer is reversed, the organic layer is combined, the anhydrous sodium sulfate is dried, and evaporated to obtain 1.04g of 7-azaindole with a yield of 40%.
Use Used as an organic synthesis reagent
Last Update：2024-04-09 21:04:16
7-Azaindole
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CAS: 271-63-6
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Wuhan Boye Science And Technology Development Co., Ltd.
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CAS: 271-63-6
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Mobile: 86-15387090420
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Jiangsu Pules Biotechnology Co.,Ltd.
Product Name: 7-Azaindole Request for quotation
CAS: 271-63-6
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Spot supply
Product Name: Atogepant Impurity 12 Visit Supplier Webpage Request for quotation
CAS: 271-63-6
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052 Click to send a QQ message
Wechat: 15671228036
Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: 7-Azaindole Visit Supplier Webpage Request for quotation
CAS: 271-63-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Wuhan Boye Science And Technology Development Co., Ltd.
Product Name: 7-Azaindole Request for quotation
CAS: 271-63-6
Tel: 86-10-10086 81625225
Email: yeqim@boyechemicals.com
Mobile: 86-15387090420
QQ: 1377812380 Click to send a QQ message
Wechat: 15387090420
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7-Azaindole
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