Molecular Formula | C23H24O6 |
Molar Mass | 396.433 |
Solubility | Soluble in DMSO |
Storage Condition | -20℃ |
Use | Dimethoxycurcumin is a more metabolically stable analog of curcumin, inducing epigenetic changes in leukemia cells and the expression of promoter methylated genes. |
Reference Show more | 1: Zhao H, Liu Q, Wang S, Dai F, Cheng X, Cheng X, Chen W, Zhang M, Chen D. In vitro additive antitumor effects of dimethoxycurcumin and 5-fluorouracil in colon cancer cells. Cancer Med. 2017 Jul;6(7):1698-1706. doi: 10.1002/cam4.1114. Epub 2017 Jun 2. PubMed PMID: 28573788; PubMed Central PMCID: PMC5504307. 2: Teymouri M, Barati N, Pirro M, Sahebkar A. Biological and pharmacological evaluation of dimethoxycurcumin: A metabolically stable curcumin analogue with a promising therapeutic potential. J Cell Physiol. 2018 Jan;233(1):124-140. doi: 10.1002/jcp.25749. Epub 2017 Mar 31. Review. PubMed PMID: 27996095. 3: Chen D, Dai F, Chen Z, Wang S, Cheng X, Sheng Q, Lin J, Chen W. Dimethoxy Curcumin Induces Apoptosis by Suppressing Survivin and Inhibits Invasion by Enhancing E-Cadherin in Colon Cancer Cells. Med Sci Monit. 2016 Sep 11;22:3215-22. PubMed PMID: 27614381; PubMed Central PMCID: PMC5021015. 4: Hassan HE, Keita JA, Narayan L, Brady SM, Frederick R, Carlson S, Glass KC, Natesan S, Buttolph T, Fandy TE. The combination of dimethoxycurcumin with DNA methylation inhibitor enhances gene re-expression of promoter-methylated genes and antagonizes their cytotoxic effect. Epigenetics. 2016 Sep 2:1-10. [Epub ahead of print] PubMed PMID: 27588609; PubMed Central PMCID: PMC5094623. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.522 ml | 12.612 ml | 25.225 ml |
5 mM | 0.504 ml | 2.522 ml | 5.045 ml |
10 mM | 0.252 ml | 1.261 ml | 2.522 ml |
5 mM | 0.05 ml | 0.252 ml | 0.504 ml |