7-Hydroxy-4-(trifluoromethyl)-2H-chromen-2-one

Name	7-Hydroxy-4-(trifluoromethyl)coumarin
Synonyms	TFMU TIMTEC-BB SBB006559 TRIFLUOROMETHYLUMBELLIFERONE 4-(TRIFLUOROMETHYL)UMBELLIFERON 4-(TRIFLUOROMETHYL)UMBELLIFERONE 7-HYDROXY-4-(TRIFLUOROMETHYL)COUMARIN 7-Hydroxy-4-(trifluoromethyl)coumarin 7-HYDROXY-4-TRIFLUOROMETHYL-CHROMEN-2-ONE 7-HYDROXY-4-(TRIFLUOROMETHYL)-2H-CHROMEN-2-ONE 7-Hydroxy-4-(trifluoromethyl)-2H-chromen-2-one 7-Hydroxy-4-(trifluoromethyl)-2H-1-benzopyran-2-one 2H-1-Benzopyran-2-one, 7-hydroxy-4-(trifluoromethyl)-
CAS	575-03-1
EINECS	124-586-5
InChI	InChI=1/C10H5F3O3/c11-10(12,13)7-4-9(15)16-8-3-5(14)1-2-6(7)8/h1-4,14H
InChIKey	CCKWMCUOHJAVOL-UHFFFAOYSA-N

Molecular Formula	C10H5F3O3
Molar Mass	230.14
Density	1.4435 (estimate)
Melting Point	178-180 °C (lit.)
Boling Point	311.4±42.0 °C(Predicted)
Flash Point	142.2°C
Solubility	DMF: soluble
Vapor Presure	0.000308mmHg at 25°C
Maximum wavelength(λmax)	330nm(Toluene)(lit.)
BRN	210932
pKa	7.23±0.20(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.546
MDL	MFCD00037578

Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R25 - Toxic if swallowed
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	UN 2811 6.1/PG 3
WGK Germany	3
FLUKA BRAND F CODES	8-10
HS Code	29322090
Hazard Class	IRRITANT

introduction	research shows that 7-hydroxy -4-trifluoromethyl coumarin compounds have a great improvement over 4-methyl -7 hydroxy coumarin derivatives in terms of water solubility and antibacterial activity, it has good antibacterial activity against rice sheath blight fungus, cucumber anthracnose fungus, strawberry gray mold fungus, wheat scab fungus, apple spot fungus, tomato early blight fungus, and has broad-spectrum antibacterial activity. It is expected to develop into a class of antibacterial agents with broad application prospects.
preparation method	3-hydroxyphenol (11g,100mmol) and ethyl trifluoroacetoacetate (15mL,100mmol) were added to concentrated phosphoric acid (52mL,85%). After stirring at room temperature for 12 hours, the reaction mixture was poured into 150mL of water. The crude product was collected by filtration and purified by recrystallization in ethanol.
use	suitable for use as pH indicator

Last Update：2024-04-10 22:29:15

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