7-Isorhynchophylline
Isorhynchophylline
CAS: 6859-01-4
Molecular Formula: C22H28N2O4
7-Isorhynchophylline - Names and Identifiers
| Name | Isorhynchophylline |
| Synonyms | SUCROSE(USP)(RG) Isorhyncophylline Isorhychophylline Isorhynchophylline ISORHYNCHOPHYLLINE 7-Isorhyncophylline 7-Isorhynchophylline ISORHYNCHOPHYLLINE (P) ISORHYNCHOPHYLLINE (RG) methyl (16E,20alpha)-16-(methoxymethylidene)-2-oxocorynoxan-17-oate (16E,20-alpha)-16,17-Didehydro-17-methoxy-2-oxo-corynoxan-16-carboxylic acid (16E,20α)-16,17-Didehydro-17-methoxy-2-oxocorynoxan-16-carboxylic acid methyl ester (7S,16E,20R)-16,17-Didehydro-17-methoxy-2-oxocorynoxan-16-carboxylic acid methyl ester Corynoxan-16-carboxylic acid, 16,17-didehydro-17-methoxy-2-oxo-, methyl ester, (16E,20-alpha)- |
| CAS | 6859-01-4 |
| InChI | InChI=1/C22H28N2O4/c1-4-14-12-24-10-9-22(17-7-5-6-8-18(17)23-21(22)26)19(24)11-15(14)16(13-27-2)20(25)28-3/h5-8,13-15,19H,4,9-12H2,1-3H3,(H,23,26)/b16-13+/t14-,15-,19-,22-/m0/s1 |
7-Isorhynchophylline - Physico-chemical Properties
| Molecular Formula | C22H28N2O4 |
| Molar Mass | 384.47 |
| Density | 1.23 |
| Melting Point | 114℃ |
| Boling Point | 560.8±50.0 °C(Predicted) |
| Specific Rotation(α) | +13 (+8.3) (CHCl3) |
| Flash Point | 293°C |
| Solubility | Soluble in chloroform |
| Vapor Presure | 1.32E-12mmHg at 25°C |
| Appearance | White crystalline powder |
| pKa | 13.61±0.60(Predicted) |
| Storage Condition | 2-8℃ |
| Refractive Index | 1.596 |
| MDL | MFCD22124712 |
| Physical and Chemical Properties | White crystalline powder, soluble in chloroform, derived from Uncaria. |
7-Isorhynchophylline - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| HS Code | 29389090 |
7-Isorhynchophylline - Reference
| Reference Show more | 1. Wang, Mei, Sun, gang. Determination of rhynchophylline and isorhynchophylline in Anle tablets by HPLC [J]. Chinese drug Standard 2017(4). 2. Zhang Yuan-yuan, Zeng Hui-ting, Chen Chao et al. Separation and determination of rhynchophylline and isorhynchophylline in Uncaria by HPLC with ionic liquid as mobile phase additive [J]. China pharmacy 2019 v.30;No.663(21):77-82. 3. Guo Xiaomin, Huang Baoyuan, Zeng Chang Qing. Screening of Uncaria alkaloid extract and its monomer to reverse drug resistance activity of HepG2/ADM cells [J]. Journal of Guangdong Pharmaceutical College, 2018, 034(004):447-451. 4. [IF = 3.935] Shuanglu Xie et al."Systematic identification and quantification of tectyclic monoterpenoid oxindole alkaloids in Uncaria rhynchophylla and their fragmentations in Q-TOF-MS spectra." J Pharmaceut Biomed. 2013 Jul;81-82:56 5. [IF = 1.908] Xin Wang et al."Stereoselective pharmacokinetic study of rhynchophylline and isorhynchophylline epimers in rat plasma by liquid chromatography-tandem mass spectrometry."Xenobiotica. 2017;47(6):479-487 6. [IF=4.759] Keyu Feng et al."Configuration of the ion exchange chromatography, hydrophilic interaction chromatography, and reversed-phase chromatography as off-line three-dimensional chromatography coupled with high-resolution quadrupole-Orbitrap mass spectrometry fo 7. [IF=3.935] Wenwen Huang et al."Rapid discovery of potentially vasodilative compounds from Uncaria by UHPLC/Q-Orbitrap-MS based metabolomics and correlation analysis."J Pharmaceut Biomed. 2021 Nov;206:114384 8. [IF=3] Qu Lala et al."Phenotypic assessment and ligand screening ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950 9. [IF=6.529] Lingling Xie et al."Uncaria Rhynchophylla attenuates angiotensin Ⅱ-induced myocardial fibrosis via suppression of the RhoA/ROCK1 pathway."Biomed Pharmacother. 2022 Feb;146:112607 |
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