7-chloroquinolin-4(1H)-one

7-chloroquinolin-4(1H)-one - Names and Identifiers

Name	7-chloroquinolin-4-ol
Synonyms	7-chloroquinolin-4-ol 7-Chloroquinolin-4-ol 7-CHLORO-4-QUINOLINOL 7-chloro-4-quinolinol 4-Quinolinol, 7-chloro- 7-CHLORO-4-HYDROQUINOLINE 7-CHLORO-4(1H)-QUINOLINONE 7-chloroquinolin-4(1H)-one 4-Hydroxy-7-chloroquinoline 7-Chloro-4-hydroxyquinoline 7-CHLORO-4-HYDROXYQUINOLINE 7-Chloro-4(1H)-quinolinone([2383-97-8])
CAS	86-99-7
EINECS	201-715-2
InChI	InChI=1/C9H6ClNO/c10-6-1-2-7-8(5-6)11-4-3-9(7)12/h1-5H,(H,11,12)

7-chloroquinolin-4(1H)-one - Physico-chemical Properties

Molecular Formula	C9H6ClNO
Molar Mass	179.6
Density	1.412±0.06 g/cm3(Predicted)
Melting Point	276-279°C(lit.)
Boling Point	348.5±22.0 °C(Predicted)
Flash Point	136.9°C
Vapor Presure	0.000966mmHg at 25°C
BRN	125356
pKa	3.86±0.40(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.608
MDL	MFCD00006778
Physical and Chemical Properties	Colorless needle-like crystals. Melting point 276-280 ℃, micro-soluble in cold water, soluble in hot water.

7-chloroquinolin-4(1H)-one - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection
WGK Germany	3

7-chloroquinolin-4(1H)-one - Reference Information

uses

pharmaceutical and dye intermediates. It can be used to synthesize the anti-cancer drug chloroquine phosphate.

production method

in the laboratory, can be heated 7-chloro-4-hydroxyquinoline-3-carboxylic acid derived. A large number of bubbles were generated when heated to 250-270 °c. When the evolution of the bubbles stopped, it was cooled, and the reaction solution was decanted. After cooling, a crude solid product was obtained, which was recrystallized with water. The crude yield was 98%. Industrial production can be started from M-chloroaniline, by condensation, cyclization, hydrolysis and 7-chloro-4-hydroxyquinoline-3-carboxylic acid, which is heated together with paraffin oil to eliminate, the upper layer of paraffin oil in the product was removed to obtain 7-chloro-4-hydroxyquinoline.

Last Update：2024-04-09 21:54:55