70-55-3

70-55-3 - Names and Identifiers

Name	p-Toluenesulfonamide
Synonyms	PTSA PASAM Tosylamide Uniplex 173 P-TOLUENESULFONAMIDE 4-TOLUENESULFONAMIDE Photoinitiator-6105l p-Toluenesulfonamide p-Toluenesulphonamide Toluene-4-sulfonamide P-TOLUENESULPHONAMIDE 4-Toluene sulfonamide P-TOLUENE SULFONAMIDE p-Toluenesulfonylamide P-TOLUENESULFONYLAMIDE Toluene-4-sulphonamide P-toluene sulfonylamine Para-Toluene Sulfonamide 4-METHYLBENZENESULFONAMIDE 4-Methylbenzenesulfonamide 4-TOLUENESULFONIC ACID AMIDE Ortho Para-Toluene Sulfonamide
CAS	70-55-3
EINECS	200-741-1
InChI	InChI=1/C7H9NO2S/c1-6-2-4-7(5-3-6)11(8,9)10/h2-5H,1H3,(H2,8,9,10)

70-55-3 - Physico-chemical Properties

Molecular Formula	C7H9NO2S
Molar Mass	171.22
Density	1.2495 (rough estimate)
Melting Point	134-137 °C (lit.)
Boling Point	221 °C (10 mmHg)
Flash Point	202 °C
Water Solubility	0.32 g/100 mL (25 º C)
Solubility	Soluble in alcohol, very slightly soluble in water.
Vapor Presure	0.000285mmHg at 25°C
Vapor Density	5.9 (vs air)
Appearance	White crystal
Color	White
Odor	Odorless
BRN	472689
pKa	10.20±0.10(Predicted)
Storage Condition	Store below +30°C.
Sensitive	Easily absorbing moisture
Refractive Index	1.6100 (estimate)
MDL	MFCD00011692
Physical and Chemical Properties	Appearance white crystals melting point 136-140°C boiling point 221°C (10 mmHg) flash point 202°C water-soluble 0.32g/100 mL (25°C)
Use	Used in the manufacture of plasticizers, disinfectants, can also be used in the production of synthetic resins, coatings, fluorescent dyes, etc

70-55-3 - Risk and Safety

Risk Codes	R36 - Irritating to the eyes R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
WGK Germany	1
RTECS	XT5075000
TSCA	Yes
HS Code	29350090
Packing Group	III

70-55-3 - Upstream Downstream Industry

Raw Materials	Terephthaloyl chloride Ammonia
Downstream Products	Gliclazide

70-55-3 - Nature

Open Data Verified Data

White Flake Crystal, flammable. Soluble in ethanol, insoluble in water and ether. The melting point was 138.5-139 °c. The melting point of the hydrate was 105 °c.

Last Update：2024-01-02 23:10:35

70-55-3 - Preparation Method

Open Data Verified Data

chlorosulfonation of toluene with chlorosulfonic acid yields O-and p-Toluenesulfonyl chlorides. The p-Toluenesulfonyl chloride (see O-toluenesulfonamide) was separated by freezing crystallization method, and then the crude p-toluenesulfonamide was obtained by ammoniation with ammonia, and then decolorized by activated carbon, filtered and acid, to obtain a finished product.

Last Update：2022-01-01 10:55:50

70-55-3 - Introduction

Median lethal dose (mice, abdominal cavity) 250mg/kg.

Last Update：2022-10-16 17:28:03

70-55-3 - Use

Open Data Verified Data

used in organic synthesis, but also in the manufacture of dyes (such as fluorescent dyes), plasticizers, synthetic resins, coatings, disinfectants, fungicides, etc, it is also used in the manufacture of wood processing brightener.

Last Update：2022-01-01 10:55:50

70-55-3 - Safety

Open Data Verified Data

toxic. Its toxicity and protection method see O-toluenesulfonamide.
the use of inner plastic bags, outer woven bags or inner plastic bags, middle with kraft paper bags, outer woven bags. 25kg per bag. During storage and transportation, it should be handled with care, moisture-proof and heat-proof. The flammable and toxic substances shall be stored and transported according to the regulations.

Last Update：2022-01-01 10:55:51

70-55-3 - Reference Information

NIST chemical information	information provided by: webbook.nist.gov (external link)
EPA chemical substance information	information provided by: ofmpeb.epa.gov (external link)
Introduction	p-toluenesulfonamide alias 4-toluenesulfonamide, P-sulfonamide, toluenesulfonamide, it is a white flake or leaf-like crystal, used in the synthesis of chloramine-T and chloromycetin, fluorescent dyes, plasticizers, synthetic resins, coatings, disinfectants and wood processing brighteners.
function and use	p-toluenesulfonamide is an excellent solid plasticizer for thermosetting plastics, suitable for phenolic resin, melamine resin, urea-formaldehyde resin and polyamide and other resins. A small amount of mixing can improve the processability, make the curing uniform, and give the product good gloss. P-toluenesulfonamide has no softening effect as a liquid plasticizer, is incompatible with polyvinyl chloride and vinyl chloride copolymers, and is partially compatible with cellulose acetate, cellulose acetate butyrate, and cellulose nitrate. p-toluenesulfonamide has low toxicity and is approved by the U. S. Food and Drug Administration for use in adhesives for food packaging materials. p-toluenesulfonamide referred to as TSH, commonly used as nickel brightener, through the adsorption on the electrode to improve the coating structure, can have a certain degree of surface gloss, the amount of such brightener added is generally not strictly limited, and the effect on the characteristics of the coating is also relatively small, but only semi-bright coating is obtained, and the surface gloss is related to the polishing effect of the substrate before plating. at present, the brighteners used in nickel plating are mostly organic compounds, and the amount of these organic compounds is very small, and the effect is remarkable. In addition to making the coating bright, but also largely determine the mechanical and chemical properties of the coating. However, it must be noted that due to the addition of these organic compound brighteners in the bright nickel plating solution, it is natural for the nickel plating layer to be mixed with more organic matter and sulfur and other impurities, and the internal stress will inevitably increase, therefore, the mechanical properties are worse than those of ordinary nickel plating, and the plated parts are prone to cracks when stressed, and the rust prevention ability is also worse than that of dark nickel. Therefore, a single layer of bright nickel does not improve the corrosion resistance and mechanical properties of the nickel layer, and it is necessary to form double-layer and multi-layer nickel or a protective decorative coating in combination with chromium to form a multi-layer. p-toluenesulfonamide decomposes to 105 ℃ and releases nitrogen gas (gas generation 130mL/g). P-toluenesulfonamide foaming agent has fine foaming, small product shrinkage, high tear strength and good stability. Thus a wide range of applications.
Use	used in the manufacture of dyes, plasticizers, synthetic resins, coatings, disinfectant and wood processing brightener used in the manufacture of plasticizers, disinfectants, can also be used in the production of synthetic resins, coatings, fluorescent dyes. as primary brightener in bright nickel plating. For bright multi-layer nickel plating, make the coating bright and uniform. General dosage of 0.2~0.3g/L. used in the manufacture of dyes, plasticizers, resins, coatings, Disinfectants (chloramine t), wood processing brighteners, etc. used as a plasticizer, also used in the synthesis of organic compounds, resins and saccharin organic synthesis, plasticizers, resins and coatings of the mold.
production method	is obtained by reacting p-Toluenesulfonyl chloride with aqueous ammonia. first, part of HN3 water is added into the reaction pot, P-Toluenesulfonyl chloride is added under stirring, the temperature naturally rises to above 50 ° C., and the remaining ammonia water is added after the temperature drops. The reaction was carried out at 85~90 ℃ for 0.5 h. The reaction was terminated at a pH of 8 to 9. It was cooled to 20 °c, filtered, and the filter cake was washed with water to obtain a crude product. After activated carbon decolorization, alkali dissolution, acid analysis, spin filter, dry to get the product.
toxic substance data	information provided by: pubchem.ncbi.nlm.nih.gov (external link)