70411-83-5

70411-83-5 - Names and Identifiers

Name	4-Pyridinecarbonitrile,1,2-dihydro-1-methyl-2-oxo-(9CI)
Synonyms	4-Cyano-1-Methyl-2(1H)-pyridone 1-Methyl-2-oxopyridine-4-carbonitrile 4-Pyridinecarbonitrile, 1,2-dihydro-1-methyl-2-oxo- 4-Pyridinecarbonitrile,1,2-dihydro-1-methyl-2-oxo-(9CI)
CAS	70411-83-5

70411-83-5 - Physico-chemical Properties

Molecular Formula	C7H6N2O
Molar Mass	134.14
Storage Condition	Inert atmosphere,Room Temperature

70411-83-5 - Reference Information

Introduction

1-methyl-2-oxo-4-cyano-1, 2-dihydropyridine is an organic intermediate, which can be obtained by methylation of 4-cyano-2 (1H)-pyridone or from 1-methyl-2-oxo-1, 2-Dihydropyridine-4-formamide is obtained by dehydration.

preparation

sodium hydride (0.12g;3.12mmol;1.5 equivalent) was added to a stirring solution of 4-cyano-2 (1H)-pyridone (0.25g;2.08mmol;1 equivalent) in DMF(5mL), and the resulting mixture was stirred at 0°C for 10 minutes. Methyl iodide (0.4mL;6.25mmol;3 equivalents) was then added to the mixture and the resulting mixture was stirred at 23°C for 2h. Dilute the mixture with water (50mL)

and extract the organic components (2 × 200mL) with ethyl acetate. Wash the combined organic layer with water and brine, dry on anhydrous sodium sulfate, filter and remove the solvent in vacuum to obtain the title compound (0.18g,67%).

Last Update：2024-04-09 21:04:16