704869-38-5
SUN11602
CAS: 704869-38-5
Molecular Formula: C26H37N5O2
704869-38-5 - Names and Identifiers
| Name | SUN11602 |
| Synonyms | CS-2504 SUN11602 4-[[4-[[2-[(4-Amino-2,3,5,6-tetramethylphenyl)amino]acetyl]methylamino]-1-piperidinyl]methyl]benzamide |
| CAS | 704869-38-5 |
704869-38-5 - Physico-chemical Properties
| Molecular Formula | C26H37N5O2 |
| Molar Mass | 451.60428 |
| Solubility | Soluble in DMSO, not in water |
| Storage Condition | -20℃ |
| Use | SUN11602 is a novel aniline compound, which mimics the neuroprotective mechanisms of basic fibroblast growth factor. In primary cultures of rat cerebrocortical neurons, SUN11602 and bFGF prevented glutamate-induced neuronal death. |
| In vitro study | SUN11602 prevents glutamate-induced neuronal death in primary cultures of rat cerebrocortical neurons. SUN11602 increases the levels of CALB1 gene expression in cerebrocortical neurons. SUN11602 exerts protective effects on hippocampal neurons through activation of FGFR1 and increases CalB expression. SUN11602 promotes neurite outgrowth of primarily cultured rat hippocampal neurons. |
| In vivo study | In WT mice, SUN11602 increases the levels of newly synthesized Calb in cerebrocortical neurons and suppresses the glutamate-induced rise in intracellular Ca 2+ . This Ca 2+ -capturing ability of Calb allows the neurons to survive severe toxic conditions of glutamate. Oral administration of SUN11602 at the midpoint of Aβ1-40 and ibotenate injections attenuate short-term memory impairment in the Y-maze test, as well as spatial learning deficits in the water maze task. In addition, the SUN11602 treatment inhibits the increase of peripheral-type benzodiazepine-binding sites (PTBBS),which are a marker for gliosis. |
704869-38-5 - Reference
| Reference Show more | 1: Murayama N, Noshita T, Ogino R, Masuda T, Kadoshima T, Oka T, Ueno N, Takemoto N, Toba T, Ueno S, Schulze W, Igawa Y, Morita Y, Inoue T. SUN11602-induced hyperexpression of calbindin D-28k is pivotal for the survival of hippocampal neurons under neurotoxic conditions. Brain Res. 2015 Jan 12;1594:71-81. doi: 10.1016/j.brainres.2014.10.066. PubMed PMID: 25449889. 2: Ogino R, Murayama N, Noshita T, Takemoto N, Toba T, Oka T, Narii N, Yoshida S, Ueno N, Inoue T. SUN11602 has basic fibroblast growth factor-like activity and attenuates neuronal damage and cognitive deficits in a rat model of Alzheimer's disease induced by amyloid β and excitatory amino acids. Brain Res. 2014 Oct 17;1585:159-66. doi: 10.1016/j.brainres.2014.08.023. PubMed PMID: 25130662. 3: Murayama N, Kadoshima T, Takemoto N, Kodama S, Toba T, Ogino R, Noshita T, Oka T, Ueno S, Kuroda M, Shimmyo Y, Morita Y, Inoue T. SUN11602, a novel aniline compound, mimics the neuroprotective mechanisms of basic fibroblast growth factor. ACS Chem Neurosci. 2013 Feb 20;4(2):266-76. doi: 10.1021/cn300183k. PubMed PMID: 23421678; PubMed Central PMCID: PMC3582292. |
704869-38-5 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.214 ml | 11.072 ml | 22.143 ml |
| 5 mM | 0.443 ml | 2.214 ml | 4.429 ml |
| 10 mM | 0.221 ml | 1.107 ml | 2.214 ml |
| 5 mM | 0.044 ml | 0.221 ml | 0.443 ml |
Last Update：2024-01-02 23:10:35
704869-38-5 - Reference Information
| biological activity | SUN11602 is a novel basic aniline compound with fibroblast growth factor activity. |
Last Update：2024-04-09 15:16:56
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