722456-31-7
1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide
CAS: 722456-31-7
Molecular Formula: C18H12N6OS
722456-31-7 - Names and Identifiers
722456-31-7 - Physico-chemical Properties
| Molecular Formula | C18H12N6OS |
| Molar Mass | 360.39 |
| Density | 1.53±0.1 g/cm3(Predicted) |
| Boling Point | 627.0±65.0 °C(Predicted) |
| Solubility | DMSO : 83.3 mg/mL (231.14 mM; Need ultrasonic) |
| Appearance | Tan solid |
| Color | white to beige |
| pKa | 0.85±0.30(Predicted) |
| Storage Condition | room temp |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| In vitro study | VAS2870 is effective to suppress PDGF-BB-dependent activation of NADPH oxidase and subsequent production of intracellular ROS. Furthermore, VAS2870 suppresses PDGF-BB-dependent chemotaxis, but not DNA synthesis. Preincubation with VAS2870 (10 and 20 μM) completely abolishes PDGF-mediated NADPH oxidase activation and ROS production. Preincubation with VAS2870 (0.1-20 μM) does not affect PDGF-induced cell cycle progression. However, it abolishes PDGF-dependent chemotaxis of VSMC in a concentration-dependent manner (100% inhibition at 10 μM). VAS2870 inhibits dose-dependently autocrine increase of cell number in FaO rat hepatoma cells, and almost completely blocked ROS production and thymidine incorporation when used at 25 mM. VAS2870 blocks serum-dependent cell growth of FaO rat hepatoma cells. VAS2870 inhibits proliferation of different human hepatocellular carcinoma (HCC) cell lines. VAS2870 pretreatment enhances TGF-b-mediated apoptosis of FaO rat hepatoma cells. |
722456-31-7 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| WGK Germany | 3 |
722456-31-7 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.775 ml | 13.874 ml | 27.748 ml |
| 5 mM | 0.555 ml | 2.775 ml | 5.55 ml |
| 10 mM | 0.277 ml | 1.387 ml | 2.775 ml |
| 5 mM | 0.055 ml | 0.277 ml | 0.555 ml |
Last Update：2024-01-02 23:10:35
722456-31-7 - Reference Information
| introduction | VAS-2870 (722456-31-7) is a NAD(P)H oxidase (Nox) inhibitor. It can inhibit PMA-induced oxidative reaction in HL-60 cells (IC50=2 μM) and enhance TGF-β-induced apoptosis of liver tumor cells. |
| biological activity | VAS2870 is a pan-NADPH oxidase(NOX) inhibitor. |
| target | TargetValue NADPH oxidase () |
| Target | Value |
| in vitro study | VAS2870 is effective to suppress PDGF-BB-dependent activation of NADPH oxidase and subsequent production of intracellular ROS. Furthermore, VAS2870 suppresses PDGF-BB-dependent chemotaxis, but not DNA synthesis. Preincubation with VAS2870 (10 and 20 μM) completely abolishes PDGF-mediated NADPH oxidase activation and ROS production. Preincubation with VAS2870 (0.1-20 μM) does not affect PDGF-induced cell progression. However, it abolishes PDGF-dependent chemotaxis of VSMC in a concentration-dependent manner (100% inhibition at 10 μM). VAS2870 inhibits dose-dependently autocrine increase of cell number in FaO rat hepatoma cells, and almost completely blocked ROS production and thymidine incorporation when used at 25 mM. VAS2870 blocks series-dependent cell growth of FaO rat hepatoma cells. VAS2870 inhibits proliferation of different human hepatocellular carcinoma (HCC) cell lines. VAS2870 pretreatment enhances TGF-b-mediated apoptosis of FaO rat hepatoma cells. |
Last Update：2024-04-09 20:02:46
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Product Name: 1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide Visit Supplier Webpage Request for quotationCAS: 722456-31-7
Tel: 18301782025
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Wechat: 18301782025
Spot supply
Product Name: 1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide Visit Supplier Webpage Request for quotationCAS: 722456-31-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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