72296-47-0

Name	Apovincaminic Acid Hydrochloride Salt
Synonyms	Vinpocetine Carboxylic Acid HCl Apovincaminic Acid Hydrochloride Salt ApovincaMinic Acid Hydrochloride Salt Vinpocetine Carboxylic Acid HCl (Apovincaminic Acid HCl)
CAS	72296-47-0

Molecular Formula	C20H23ClN2O2
Molar Mass	358.87
Melting Point	>236°C (dec.)
Solubility	DMSO (Slightly), Methanol (Slightly), Water (Very Slightly)
Appearance	Solid
Color	White
Storage Condition	Hygroscopic, Refrigerator, under inert atmosphere

biological activity	Apovincaminic acid hydrate salt is Vinpocetine (VP) A major active metabolite that is orally active and can cross the blood-brain barrier. Apovincaminic acid hydrate salt has a neuroprotective effect.
Animal Model:	Male Harlan‐Wistar rats (300-400 g) are injected NMDA
Dosage:	10 mg/kg
Administration:	I.p. twice daily for 4 days
Result:	Attenuated the attention deficit effectively. Prevented the learning and memory impairment in the spontaneous alternation and Morris water maze tests. significantly reduced lesion size microglia activation.

Last Update：2024-04-09 21:11:58