74-89-5

74-89-5 - Names and Identifiers

Name	Methylamine
Synonyms	CH3NH2 Methylamin Methylamine mercurialin Carbinamine Aminomethan methanamine Methanamine Aminomethane Monomethylamine methylamine(mono) anhydrousmethylamine Monomethylamine anhydrous methylamine(non-specificname)
CAS	74-89-5
EINECS	200-820-0
InChI	InChI=1/CH5N/c1-2/h2H2,1H3

74-89-5 - Physico-chemical Properties

Molecular Formula

CH5N

Molar Mass

31.06

Density

0.785g/mLat 25°C

Melting Point

-93°C(lit.)

Boling Point

-6.3°C(lit.)

Flash Point

61°F

Water Solubility

Miscible with water, ethanol, benzene, acetone and ether.

Solubility

highly soluble in water (108g/100g) at 25°C; soluble in alcohol andmiscible with ether; HCl salt is soluble in water and absolute alcohol; compoundis insoluble in chloroform, acetone, ether, and ethyl acetate

Vapor Presure

27 psi ( 20 °C)

Vapor Density

1.08 (20 °C, vs air)

Appearance

Gas

Specific Gravity

0.901 (20℃/4℃) (40% Soln.)

Exposure Limit

TLV-TWA 10 ppm (～12.3 mg/m3)(ACGIH,MSHA, and OSHA); IDLH 100 ppm(NIOSH).

Merck

14,6014

BRN

741851

pKa

10.63(at 25℃)

14 (H2O, 20°C)

Storage Condition

Store below +30°C.

Stability

Stable. Highly flammable. Note wide explosion limits. Incompatible with oxidizing agents, acids, alkalies, alkaline earth metals, copper and its alloys, zinc and its alloys.

Explosive Limit

4.9-20.8%

Refractive Index

n20/D 1.371

Physical and Chemical Properties

bp (°C):

48
225	- 230	(p=15 torr)
40
225	- 230	(p=15 torr)

mp (°C):

	194

density:

	0.9

nd:

1.365

- 1.37

Use

Used as basic organic chemical raw materials, also used in pesticide, pharmaceutical, textile and other industries

74-89-5 - Risk and Safety

Risk Codes	R12 - Extremely Flammable R20 - Harmful by inhalation R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes R34 - Causes burns R20/22 - Harmful by inhalation and if swallowed. R11 - Highly Flammable R39/23/24/25 - R36/37/38 - Irritating to eyes, respiratory system and skin. R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R40 - Limited evidence of a carcinogenic effect R19 - May form explosive peroxides
Safety Description	S7 - Keep container tightly closed. S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S29 - Do not empty into drains. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S3/7 - S3 - Keep in a cool place. S39 - Wear eye / face protection. S33 - Take precautionary measures against static discharges.
UN IDs	UN 3286 3/PG 2
WGK Germany	2
RTECS	PF6300000
FLUKA BRAND F CODES	4.5-31
TSCA	Yes
HS Code	29211100
Hazard Class	3
Packing Group	II
Toxicity	LD50 orally in rats: 100-200 mg/kg (Kinney); LC50 in rats: 0.448 ml/l (Sarkar, Sastry)

74-89-5 - Upstream Downstream Industry

Downstream Products

1-Methyl-2-pyrrolidinone
N-Methyl acetoacetylamide
1,3-Dimethylurea
dimethoate
2-Mercapto-1-methylimidazole
Kathon 886

74-89-5 - Nature

Open Data Verified Data

It is a colorless ammonia-odorous gas or liquid at room temperature. Soluble in water, ethanol and ether. The vapor can form an explosive mixture with air, and the explosion limit is 526 ~ 21% (4.95% ~ 20.7526). The relative density was 0.662. Melting Point -93.5 °c. Boiling point -6. 3 ~-6.7 °c. Decomposition temperature 250. Flash point (closed cup) 0. Spontaneous ignition point 430. Vapor pressure (25 °c) 202. The critical temperature is 156.9. The critical pressure is 4. 073kPa. Refractive index 351. 40%-methylamine aqueous solution boiling point 49.4 deg C. Point -9.94 °c. Relative density (d15.5) 0.904.

Last Update：2024-01-02 23:10:35

74-89-5 - Preparation Method

Open Data Verified Data

a compounding ratio of methanol and ammonia of 1 :( 1.5-4) at high temperature (425 ° C.) and high pressure (2. 45MPa), using activated alumina as catalyst for continuous gas phase catalytic reaction to produce a mixture of one, two and three methyl amine, and then through a series of distillation column continuous pressure distillation separation, condensation deammoniation, dehydration, can be obtained one, two, three methylamine industrial products, but also according to user needs with 40% of the one, two, three methylamine solution for sale.
According to the relevant literature, changing the ratio of methanol and ammonia is an effective method to obtain the desired product, and the ratio of methanol and ammonia is 1:1.5, which is the best condition for the formation of trimethylamine, methanol and ammonia ratio of 1:4 is the best conditions for the formation of methylamine.

Last Update：2022-01-01 10:34:20

74-89-5 - Use

Open Data Verified Data

This product is mainly used as pesticide (dimethoate, chlordimeform, etc.), medicine (caffeine, ephedrine, etc, raw materials such as surface inhibitors, accelerators, developers, and solvents.

Last Update：2022-01-01 10:34:19

74-89-5 - Safety

Open Data Verified Data

This product is toxic, can stimulate the skin and mucous membranes, especially for the eyes, respiratory organs. However, if the vapor is inhaled, the toxicity is smaller than that of amines with larger alkyl groups such as butylamine. On animals: the mice were killed at a concentration of 2.4 mg/L for 2 hours. The first symptoms of restlessness, bleeding discharge from the nasal cavity, Dyspnea, cyanosis, hyperreflexia, head tremor, gait instability, spasms, and finally death due to respiratory arrest. When the concentration was 0. 13mg/L, the respiratory rhythm of rabbits could be changed. Conditioned reflex activity was disrupted by inhalation of 0.05 mg/L for 40 min. A few minutes after inhalation of 0.2 mg/L, the cat showed obvious symptoms of upper respiratory tract irritation. For human: olfactory Yan, 0. 0005-0. OOlmg/L, stimulation threshold 0.Olmg/L. The maximum allowable concentration in the workplace is 1 mg/m3. When the skin is in contact with this product after application of large amounts of water rinse. Eyes splash into the product, application of running water rinse for 15 minutes. Such as inhalation of this product, should immediately move to the fresh air, drink 3~4 cups of water, so that Vomit. Wear protective equipment and gas masks when necessary. The workshop shall be well ventilated and the equipment shall be closed.
anhydrous monomethylamine is packaged in a pressure-resistant cylinder, and the monomethylamine aqueous solution is packaged in a tank car or an iron drum. Store in a cool and ventilated place, warehouse temperature should not exceed 30 ℃, should be away from fire, heat source, to prevent direct sunlight. It should also be stored separately from fluorine, chlorine, bromine, phosphine, hydrogen sulfide, hydrogen cyanide and other gases. Handling should be light and light unloading, to prevent the reverse. According to the provisions of flammable materials storage and transportation.

Last Update：2022-01-01 10:34:19

74-89-5 - Reference Information

olfactory Threshold	0.035ppm
Henry's Law Constant	(x 10-5 atm?m3/mol):1.11 at 25 °C (Christie and Crisp, 1967)
EPA chemical substance information	information provided by: ofmpeb.epa.gov (external link)
organic chemical raw materials	methylamine, also known as methylamine and aminomethane, is an important organic chemical raw materials and intermediates, at room temperature and atmospheric pressure for flammable colorless gas, high concentration or compression liquefaction, with a strong ammonia odor. Fishy odor at very low concentrations. Soluble in water, soluble in ethanol, ether. Easy to burn, form an explosive mixture with air, explosion limit: 4.3% ~ 21%. There are weak alkaline, alkaline than ammonia, and inorganic acid to generate water soluble salts. It is synthesized from methanol and ammonia under the action of high temperature and high pressure and catalyst, and can also be prepared by heating formaldehyde and ammonium chloride to 300 ℃ under the action of zinc chloride. Methylamine can be used in the manufacture of pesticides, pharmaceuticals, rubber vulcanization accelerators, dyes, explosives, leather, petroleum, surfactants, ion exchange resins, paint strippers, coatings and additives. It is an important raw material for the production of pesticide Dimethoate, carbaryl and chlordimeform. Methylamine inhalation toxicity is low toxicity class, maximum allowable concentration in the air 5mg/m3(0.4ppm). Corrosive, irritating to the eyes, skin and mucous membranes. In case of open flame, there is a risk of combustion caused by high heat, and damage to cylinders and accessories will cause explosion.
First Aid for poisoning	methylamine is a medium toxic class with strong irritation and corrosivity. In the production process and during transportation, due to accidental leakage, will cause the contact of acute poisoning. This product can be inhaled through the respiratory tract, the solution can be absorbed through the skin, and the salt can be poisoned by accidental ingestion. This product has a strong stimulating effect on the eyes, upper respiratory tract, skin and mucosa. Inhalation of high concentrations can damage the lungs. Severe cases can cause pulmonary edema, respiratory distress syndrome and death. However, no cases of systemic poisoning have been reported at home and abroad. Liquid methylamine compounds have strong irritation and corrosion, can cause eye and skin chemical burns. 40% methylamine aqueous solution can cause eye burning pain, photophobia, tears, Conjunctival Congestion, eyelid swelling, corneal edema and superficial ulcer, the symptoms can last for 1 to 2 weeks. Long-term exposure to low concentrations of methylamine compounds, can feel dry eyes, nose, throat and discomfort. [first aid measures] when the skin is in contact, take off the contaminated clothes immediately and rinse thoroughly with a large amount of flowing water, 0.5% citric acid rinses the skin, mucous membranes and gargles. when the eyes are contaminated, the eyelids should be lifted, rinsed with running water or saline for at least 15 minutes, and then examined by fluorescein staining. If there is corneal injury, an ophthalmologist should be consulted. for those who have inhaled monomethylamine gas, they should quickly leave the scene and move to a place with fresh air to keep the respiratory tract unobstructed. Dyspnea of the patients should be given oxygen inhalation, after treatment, the patient was sent to hospital for emergency treatment.
purpose	is used as a basic organic raw material for pesticide, pharmaceutical, textile and other industries, also used in water gel explosive used as solvent and refrigerant used as basic organic chemical raw materials, also used in pesticide, pharmaceutical, textile and other industries used as surfactant, polymerization inhibitors and solvents, also used in organic synthesis and printing and dyeing industry for the synthesis of efficient pesticides, pharmaceuticals, dyes, spices, etc., and for electrolysis, electroplating monomethylamine is an important aliphatic amine organic chemical raw material, which is widely used in the production of pesticides, and can be used to synthesize N-methyl chloroacetamide, which is the intermediate of organophosphorus insecticide dimethoate and omethoate; monocrotophos intermediate α-chloroacetylmethanamine; Carbamoyl chloride and methyl isocyanate as intermediates of carbamate insecticides; As well as other pesticide varieties such as monoformamidine, Amitraz, benzenesulfonon, etc. In addition, it is also used in medicine, rubber, dyes, leather industry and photosensitive materials. methylamine has a wide range of industrial applications. Methylamine can be used as medicine (activation, caffeine, ephedrine, etc.), pesticide (carbaryl, dimethoate, chloramidine, etc.), dye (alizarin intermediate, anthraquinone intermediate, etc.), explosive and fuel (water gel explosive, monomethhydrazine, etc.), surfactants, accelerators, and raw materials such as rubber aids, photographic chemicals and solvents. An intermediate for the production of agrochemicals and pharmaceuticals for the production of N-methylpyrrolidone (solvent).
production method	industrially, methylamine is synthesized from methanol and ammonia at high temperature via a converter which is occasionally equipped with an activated alumina catalyst, however, the methylation reaction does not stop at the monomethylamine stage, thus resulting in a mixture of monomethylamine, dimethylamine and trimethylamine. Control the ratio of methanol and ammonia, ammonia excess, and add water and circulation of trimethylamine is conducive to the formation of methylamine and dimethylamine, when the amount of ammonia is 2.5 times of methanol, the reaction temperature is 425 deg C, when the reaction pressure is 2.45MPa, a mixed amine of 10-12% of monomethylamine, 8-9% of dimethylamine and 11-13% of trimethylamine can be obtained. Since trimethylamine forms an azeotrope with ammonia and other methylamines at atmospheric pressure, the reaction products are separated by a combination of pressure distillation and extractive distillation. Based on the production of 1t mixed methylamine, 1500kg of methanol and 500kg of liquid ammonia are consumed. According to relevant literature reports, changing the ratio of methanol and ammonia is an effective method to get the desired product, methanol and ammonia ratio of 1:1.5 is the best conditions for the formation of trimethylamine, methanol and ammonia ratio of 1:4 is the best conditions for the formation of methylamine. There are many production methods of monomethylamine, But methanol amination is mainly used in industry. CH3OH + NH3 → CH3NH2 + H2O2CH3OH + NH3 →(CH3)2NH + 2H2O3CH3OH + NH3 →(CH3)3N + 3H2O from methanol and ammonia at a ratio of 1: 1.5~4, under high temperature and high pressure, the continuous gas phase catalytic amination reaction is carried out by using activated alumina as a catalyst, The mixed crude product of mono-, di-and trimethylamine is generated, and then separated by continuous pressure distillation through a series of distillation columns, condensed and deammoniated and dehydrated to obtain mono-, di-and trimethylamine products respectively.
category	hazardous gas
toxicity grade	high toxicity
Acute toxicity	inhalation-mouse LC50:2400 mg/m3/2 H; Subcutaneous-rat LDL0:200 mg/kg
stimulation data	Skin-guinea pig 100 mg severe
explosive hazard characteristics	explosive when mixed with air
flammability hazard characteristics	open flame, combustible under heat; Toxic NOx smoke from combustion
storage and transportation characteristics	The warehouse is ventilated and dried at low temperature; separate from other gas cylinders
fire extinguishing agent	water and sand mist
Occupational Standard	TWA 6 mg/m3; Tel 18 mg/m3
spontaneous combustion temperature	806 ° F.
DOT Classification	2.1 (Flammable gas)
toxic substance data	information provided by: pubchem.ncbi.nlm.nih.gov (external link)
immediate life-and health-threatening concentration	100 ppm

Last Update：2024-04-17 15:09:50

Shanghai Worldyang Chemical Co.,Ltd.

74-89-5

Methylamine

CAS: 74-89-5

Molecular Formula: CH5N

74-89-5 - Names and Identifiers

74-89-5 - Physico-chemical Properties

74-89-5 - Risk and Safety

74-89-5 - Upstream Downstream Industry

74-89-5 - Nature

Open Data Verified Data

74-89-5 - Preparation Method

Open Data Verified Data

74-89-5 - Use

Open Data Verified Data

74-89-5 - Safety

Open Data Verified Data

74-89-5 - Reference Information

Supplier List

74-89-5 Request for Quotation

Methylamine

CAS: 74-89-5

Molecular Formula: CH5N

74-89-5 - Names and Identifiers

74-89-5 - Physico-chemical Properties

74-89-5 - Risk and Safety

74-89-5 - Upstream Downstream Industry

74-89-5 - Nature

Open Data Verified Data

74-89-5 - Preparation Method

Open Data Verified Data

74-89-5 - Use

Open Data Verified Data

74-89-5 - Safety

Open Data Verified Data

74-89-5 - Reference Information

Supplier List

74-89-5