74457-86-6

74457-86-6 - Names and Identifiers

Name	2'-FLUORO-4'-METHOXYACETOPHENONE
Synonyms	4-ACETYL-3-FLUOROANISOLE 2'-Fluoro-4'-Methoxyacetoph... 2-FLUORO-4-METHOXYACETOPHENONE 2-Fluoro-4-methoxyacetophenone 2'-FLUORO-4'-METHOXYACETOPHENONE 2[-Fluoro-4[-methoxyacetophenone 2'-Fluoro-4'-methoxylacetophenone 1-(2-Fluoro-4-methoxyphenyl)ethanone 1-(2-FLUORO-4-METHOXYPHENYL)ETHANONE Ethanone, 1-(2-fluoro-4-Methoxyphenyl)- N-hydroxy-2-(trifluoromethyl)benzimidoyl chloride
CAS	74457-86-6
InChI	InChI=1/C8H5ClF3NO/c9-7(13-14)5-3-1-2-4-6(5)8(10,11)12/h1-4,14H/b13-7+

74457-86-6 - Physico-chemical Properties

Molecular Formula	C9H9FO2
Molar Mass	168.16
Density	1.1410 (estimate)
Melting Point	52-54°C(lit.)
Boling Point	80-85 °C (0.1 mmHg)
Flash Point	>230°F
Water Solubility	Insoluble
Vapor Presure	0.0012mmHg at 25°C
Appearance	White to bright yellow crystals
Color	Clear colorless
BRN	3539992
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.487
MDL	MFCD00042290
Physical and Chemical Properties	Melting Point: 51 - 53 Boiling Point: 80 - 85 at .1mm Hg

74457-86-6 - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection
WGK Germany	3
HS Code	29147000
Hazard Class	IRRITANT

74457-86-6 - Reference Information

application

2-fluoro-4-methoxyacetophenone can be used as an organic synthesis intermediate and a pharmaceutical intermediate, mainly used in laboratory research and development and chemical production.

preparation

1) add 200ml dichloroethane and 126g m-fluoroanisole to the flask, stir and cool to 0°C, add 135g of aluminum trichloride, add 80g of acetyl chloride dropwise at 0-10°C, control the dripping in 2 hours, and keep the temperature for 1 hour;(2) Pour the above solution into 500g of ice water, separate the oil layer, wash with clear water, concentrate dichloroethane under reduced pressure, and recrystallize the concentrate with 250ml methanol to obtain 95g of white crystal 2-fluoro-4-methoxyacetophenone.

Last Update：2024-04-10 22:29:15