74654-07-2
mPEG3-NH2
CAS: 74654-07-2
Molecular Formula: C7H17NO3
74654-07-2 - Names and Identifiers
74654-07-2 - Physico-chemical Properties
| Molecular Formula | C7H17NO3 |
| Molar Mass | 163.21 |
| Density | 0.978±0.06 g/cm3(Predicted) |
| Boling Point | 106℃ (11 Torr) |
| pKa | 8.74±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.4395 (589.3 nm 20℃ |
| In vitro study | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
74654-07-2 - Reference Information
| introduction | 3,6, 9-trioxa-1-aminodecane is an organic intermediate that can be used as a raw material to prepare 4-methylbenzene sulfonate 2-(2-(2-methoxyethoxy) ethoxy) ethyl, then it reacts with sodium azide to obtain 3,6, 9-trioxa-1-aminodecane. |
| biological activity | m-PEG3-Amine is a PROTAC connection bridge and belongs to PEG class. m-PEG3-Amine can be used to synthesize a series of PROTAC molecules. m-PEG3-Amine is a degradable (cleavable) ADC connection bridge for the synthesis of antibody drug conjugates (ADCs). |
| target | Cleavable PEGs |
| in vitro study | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
Last Update：2024-04-10 22:41:03
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