Molecular Formula | C24H37ClN2O2
|
Molar Mass | 421.01578 |
Melting Point | 91 ±2° |
Solubility | Soluble in DMSO (up to 25 mg/ml) or ethanol (up to 25 mg/ml) |
Appearance | powder |
Color | white |
Storage Condition | Desiccate at RT |
Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
In vitro study | Bepridil hydrochloride hydrate blockades of Ca 2+ -dependent action potentials in vascular smooth muscle of dog coronary artery. Bepridil hydrochloride hydrate blocks Ca currents and Na currents with IC 50 s of 0.5 μM and 30 μM, respectively in cultured ventricular cells. Bepridil hydrochloride hydrate decreases I Ks under blockade of I Kr with E4031 (5 μM), in a concentration-dependent manner. |
In vivo study | Bepridil hydrochloride hydrate exhibits a half-life of averages 33±15 hours after single-dose administration. |