Name | ahu377 isomer 2 |
Synonyms | ahu377 isomer 2 ahu377 isomer 2 2R,4S-Sacubitril LCZ 696 Impurity A LCZ 696 Impurity A Sacubitril Enantiomer Sacubitril (2S,4R)-Isomer 4-(((2R,4S)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid [1,1'-Biphenyl]-4-pentanoic acid, γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-, 4-ethyl ester, (αS,γR)- (alphaS,gammaR)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester |
CAS | 761373-05-1 |
Molecular Formula | C24H29NO5 |
Molar Mass | 411.49 |
Density | 1.151±0.06 g/cm3(Predicted) |
Melting Point | >40°C (dec.) |
Boling Point | 656.9±55.0 °C(Predicted) |
Solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Sonicated) |
Appearance | Form Solid, color White to Off-White Sticky |
Color | White to Off-White Sticky to |
pKa | 4.72±0.10(Predicted) |
Storage Condition | Hygroscopic, -20°C Freezer, Under inert atmosphere |
Stability | Temperature Sensitive |
Physical and Chemical Properties | Bioactive 2R,4S-Sacubitril is a Sacubitri impurity. The combination of Sacubitril and valsartan has anti-heart failure effect. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.43 ml | 12.151 ml | 24.302 ml |
5 mM | 0.486 ml | 2.43 ml | 4.86 ml |
10 mM | 0.243 ml | 1.215 ml | 2.43 ml |
5 mM | 0.049 ml | 0.243 ml | 0.486 ml |
Solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Sonicated) |