Name | Cyclopropylamine |
Synonyms | AURORA KA-2551 Cyloprolylamine Cyclopropanamine Cyclopropylamine CYCLOPROPYLAMINE cyclopropanamine Aminocyclopropane AMINOTRIMETHYLENE AKOS BBS-00003593 AMINOCYCLOPROPANE Cyclopropyl amine(CPA) |
CAS | 765-30-0 |
EINECS | 212-142-2 |
InChI | InChI=1/C3H7N/c4-3-1-2-3/h3H,1-2,4H2 |
InChIKey | HTJDQJBWANPRPF-UHFFFAOYSA-N |
Molecular Formula | C3H7N |
Molar Mass | 57.09 |
Density | 0.824 g/mL at 25 °C (lit.) |
Melting Point | -50 °C |
Boling Point | 49-50 °C (lit.) |
Flash Point | −14°F |
Water Solubility | Miscible with water, ethanol,ether and chloroform. |
Vapor Presure | 4.67 psi ( 20 °C) |
Appearance | Volatile Liquid |
Specific Gravity | 0.824 |
Color | Clear colorless |
BRN | 741858 |
pKa | pK1:9.10(+1) (25°C) |
Storage Condition | Store below +30°C. |
Sensitive | Lachrymatory |
Refractive Index | n20/D 1.420(lit.) |
Physical and Chemical Properties | This product is colorless liquid, B. p.49 ~ 50 ℃,n20D 1.4206, relative density 0.824, F. P.-25 ℃. |
Use | As an intermediate of ciprofloxacin, also used in the synthesis of pesticides and plant protection agents |
Risk Codes | R11 - Highly Flammable R22 - Harmful if swallowed R34 - Causes burns R36/37 - Irritating to eyes and respiratory system. |
Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S33 - Take precautionary measures against static discharges. S7/9 - |
UN IDs | UN 2733 3/PG 2 |
WGK Germany | 2 |
RTECS | GZ0685500 |
TSCA | T |
HS Code | 29213099 |
Hazard Note | Extremely Flammable/Harmful/Corrosive/Lachrymatory |
Hazard Class | 3 |
Packing Group | II |
Toxicity | LD50 orally in Rabbit: 445 mg/kg |
NIST chemical information | information provided by: webbook.nist.gov (external link) |
EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
Application | cyclopropylamine is an important intermediate in the synthesis of quinolones such as ciprofloxacin and enrofloxacin, and is also used in the preparation of pesticides and dyes, there is a greater demand in the domestic and foreign markets. |
Use | cyclopropylamine is an intermediate of the herbicide cypromazine and the insecticide cyromazine, and is also a pharmaceutical intermediate. cyclopropylamine is mainly used in organic synthesis, pharmaceutical synthesis intermediates, can be used for the synthesis of new antibacterial drug ciprofloxacin products, such as the synthesis of ciprofloxacin, enrofloxacin, sparfloxacin and other drugs. In addition, cyclopropylamine is also an important intermediate for the synthesis of pesticides, plant protectants and herbicides, such as 2-chloro-4-6-cyclopropyls-triazine, cyclopropachlor, cyclopropanine, cyclopropanosine and other cyclopropyl pesticides. |
production method | cyclopropylamine has a variety of synthetic routes:(1) 1, 3-propanediol as raw material, cyanation, cyclization, amidation, Hofmann rearrangement products;(2) gamma-butyrolactone as raw materials, by high pressure chlorination, esterification, cyclization, aminolysis, Hofmann degradation products;(3) with ethyl acetoacetate as raw material, the product was obtained by condensation and cyclization with ethylene oxide, ring-opening and re-cyclization, oximation, rearrangement and degradation. (4) 50% NaOH, sodium hypochlorite solution and cyclopropylcarboxamide were preheated to 80 ° C. And passed through a reaction tube to obtain cyclopropylamine. |
autoignition temperature | 527 ° F. |