Name | 1-Bromoadamantane |
Synonyms | 1-BroMoadaMantan Adamantyl bromide 1-Bromoadamantane 1-bromoadmantance 3-Bromoadamantane 1-Bromoadamamtane 1-Bromo adamantine 1-Adamantyl bromide 11 -BROMOADAMANTANE RARECHEM AQ TC 1019 Adamantane, 1-bromo- LABOTEST-BB LT00239617 1-broMine adaMantanone 1-BROMOADAMANTANE FOR SYNTHESIS 1-bromotricyclo(3.3.1.13,7)decane 1-Bromotricyclo[3.3.1.1(3,7)]decane 1-Bromotricycol[3.3.1.1.(1,7)decane 1-Bromotricyclo[3.3.1.1(3.7)]decane 1-Bromoadamantane,1-Adamantyl bromide |
CAS | 768-90-1 |
EINECS | 212-200-7 |
InChI | InChI=1/C10H15Br/c11-10-4-7-1-8(5-10)3-9(2-7)6-10/h7-9H,1-6H2/t7-,8+,9-,10- |
InChIKey | VQHPRVYDKRESCL-UHFFFAOYSA-N |
Molecular Formula | C10H15Br |
Molar Mass | 215.13 |
Density | 1.2686 (rough estimate) |
Melting Point | 116-118 °C (lit.) |
Boling Point | 248.79°C (rough estimate) |
Flash Point | 96.4°C |
Water Solubility | It is soluble in organic solvents and insoluble in water. |
Solubility | Chloroform (Sparingly), Ethyl Acetate (Slightly), Methanol (Slightly) |
Vapor Presure | 0.0587mmHg at 25°C |
Appearance | White to white-like crystals |
Color | White to yellow |
BRN | 1098857 |
Storage Condition | Inert atmosphere,Room Temperature |
Sensitive | Moisture Sensitive |
Refractive Index | 1.6411 (estimate) |
MDL | MFCD00074721 |
Physical and Chemical Properties | Melting point 116-118 ° C, soluble in chloroform. |
Use | Intermediates in the synthesis of amantadine hydrochloride |
Hazard Symbols | Xn - Harmful |
Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
WGK Germany | 3 |
FLUKA BRAND F CODES | 8-10-23 |
HS Code | 29035990 |
NIST chemical information | information provided by: webbook.nist.gov (external link) |
Use | pharmaceutical intermediates. is an intermediate for the synthesis of amantadine hydrochloride |
production method | is derived from the bromination of adamantane. In a dry enamel glass pan, Adamantane was added, bromine was added dropwise, the temperature was slowly increased to about 70 ° C., and the reaction was refluxed for 6 hours. With the formation of 1-bromoadamantane, the reflux temperature of the reactant was gradually increased, and finally reached 100 ° C. After completion of the reaction, the reaction mixture was left overnight. The temperature was then raised to 45 °c and the excess bromine was removed by the dropwise addition of sodium bisulfite solution. Filtration, washing of the filter cake with water to neutrality and drying gave 1-bromoadamantane. |