769944-71-0

769944-71-0 - Names and Identifiers

Name	3-(4-broMophenyl)piperidin-2-one
Synonyms	3-(4-bromophenyl)-2-Piperidinone 3-(4-broMophenyl)piperidin-2-one 2-Piperidinone, 3-(4-bromophenyl)-
CAS	769944-71-0

769944-71-0 - Physico-chemical Properties

Molecular Formula	C11H12BrNO
Molar Mass	254.12
Density	1.416±0.06 g/cm3(Predicted)
Boling Point	416.4±45.0 °C(Predicted)
pKa	16.07±0.40(Predicted)
Storage Condition	Sealed in dry,Room Temperature

769944-71-0 - Reference Information

use

3-(4-bromophenyl) piperidin-2-one can be used as an intermediate in pharmaceutical synthesis.

application

3-(4-bromophenyl) piperidin-2-one can be used as an intermediate in pharmaceutical synthesis, such as preparation:

specific steps are as follows: 3-(4-bromophenyl) piperidin-2-one (7.6g,30mmol) was mixed in deuterated methanol (100g), heated to 40-45 ℃ under nitrogen protection, sodium methoxide (3.2g,60mmol) was added, and reacted at 40-45 ℃ for 16h. LCMS detection showed that the deuterated rate was 90%, and the reaction solution was cooled to 20-25 ℃, 100mL of ammonium chloride solution was added for quenching, extracted with ethyl acetate (100mL × 2), dried, concentrated to obtain crude product, and filtered with petroleum ether beating to obtain a white solid of 7.0g of 3-(4-bromophenyl)-3-deuterated piperidine -2-one with 92% yield. LCMS analysis showed that the deuteration rate was 92%, and nuclear magnetic resonance showed that the deuteration rate was 94%.

Last Update：2024-04-09 20:52:54