78239-71-1
2-Bromo-4-(bromomethyl)-1-fluorobenzene
CAS: 78239-71-1
Molecular Formula: C7H5Br2F
78239-71-1 - Names and Identifiers
78239-71-1 - Physico-chemical Properties
| Molecular Formula | C7H5Br2F |
| Molar Mass | 267.92 |
| Density | 1.923±0.06 g/cm3(Predicted) |
| Melting Point | 41 °C |
| Boling Point | 259.8±25.0 °C(Predicted) |
| Water Solubility | Slightly soluble in water. |
| Solubility | soluble in Methanol |
| Appearance | Solid |
| Color | White |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Sensitive | Lachrymatory |
78239-71-1 - Risk and Safety
| UN IDs | 3261 |
| Hazard Class | 8 |
| Packing Group | II |
78239-71-1 - Introduction
2-Bromo-4-(bromomethyl)-1-fluorobenzene, chemical formula C7H6Br2F, is an organic compound.
Nature:
-Appearance: colorless liquid
-boiling point: 185-187 ℃
-Density: 1.873g/cm3
-melting point: 18-20 ℃
-Molecular weight: 265.93g/mol
-Solubility: Soluble in organic solvents such as ethers and alcohols
Use:
- 2-Bromo-4-(bromomethyl)-1-fluorobenzene is mainly used for intermediates in organic synthesis reactions and drug synthesis. It is often used in the synthesis of organic fluorescent dyes, pharmaceutical intermediates and pesticides. It can also be used as a reagent in scientific research.
Preparation Method:
2-Bromo-4-(bromomethyl)-1-fluorobenzene can be synthesized by the following steps:
1. react 4-fluorobenzyl bromide with cuprous bromide to generate 3-bromo -4-fluorobenzyl cuprous.
2. 3-bromo-4-fluorobenzylcuprous reacts with stannous bromide to generate 3-bromo-4-fluorobenzyltin compounds.
3. Finally, 3-bromo-4-fluorobenzyltin compound is reacted with bromide to prepare 2-Bromo-4-(bromomethyl)-1-fluorobenzene.
Safety Information:
- 2-Bromo-4-(bromomethyl)-1-fluorobenzene is an organic bromide, avoid prolonged contact with skin and inhalation. Can cause eye and skin irritation and have effects on the central nervous system.
-When using and handling, laboratory safety measures must be followed and personal protective equipment, such as gloves and goggles, must be used.
-Should be stored in a cool, dry place, away from fire and oxidizing agents.
-The compound should be handled in accordance with local chemical management regulations, and waste treatment should be carried out as needed.
Nature:
-Appearance: colorless liquid
-boiling point: 185-187 ℃
-Density: 1.873g/cm3
-melting point: 18-20 ℃
-Molecular weight: 265.93g/mol
-Solubility: Soluble in organic solvents such as ethers and alcohols
Use:
- 2-Bromo-4-(bromomethyl)-1-fluorobenzene is mainly used for intermediates in organic synthesis reactions and drug synthesis. It is often used in the synthesis of organic fluorescent dyes, pharmaceutical intermediates and pesticides. It can also be used as a reagent in scientific research.
Preparation Method:
2-Bromo-4-(bromomethyl)-1-fluorobenzene can be synthesized by the following steps:
1. react 4-fluorobenzyl bromide with cuprous bromide to generate 3-bromo -4-fluorobenzyl cuprous.
2. 3-bromo-4-fluorobenzylcuprous reacts with stannous bromide to generate 3-bromo-4-fluorobenzyltin compounds.
3. Finally, 3-bromo-4-fluorobenzyltin compound is reacted with bromide to prepare 2-Bromo-4-(bromomethyl)-1-fluorobenzene.
Safety Information:
- 2-Bromo-4-(bromomethyl)-1-fluorobenzene is an organic bromide, avoid prolonged contact with skin and inhalation. Can cause eye and skin irritation and have effects on the central nervous system.
-When using and handling, laboratory safety measures must be followed and personal protective equipment, such as gloves and goggles, must be used.
-Should be stored in a cool, dry place, away from fire and oxidizing agents.
-The compound should be handled in accordance with local chemical management regulations, and waste treatment should be carried out as needed.
Last Update：2024-04-09 21:00:56
