78824-30-3

Name	Garcinol
Synonyms	802 CP-54 Garcinol garcinol Camboginol (1R,5R,7R)-3-(3,4-Dihydroxybenzyol)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]bicyclo[3.3.1]non-3-ene-2,9-dione (1R,5R,7R)-3-(3,4-Dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-Bicyclo[3.3.1]non-3-ene-2,9-dione Bicyclo[3.3.1]non-3-ene-2,9-dione, 3-(3,4-dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-, (1R,5R,7R)- (1R,3E,5R,7R)-3-[(3,4-dihydroxyphenyl)-hydroxy-methylidene]-8,8-dimethyl-1,7-bis(3-methylbut-2-enyl)-5-[(2S)-5-methyl-2-prop-1-en-2-yl-hex-4-enyl]bicyclo[3.3.1]nonane-2,4,9-trione
CAS	78824-30-3
EINECS	200-258-5

Molecular Formula	C38H50O6
Molar Mass	602.8
Density	1.114±0.06 g/cm3(Predicted)
Melting Point	132 °C
Boling Point	710.8±60.0 °C(Predicted)
Specific Rotation(α)	-143 (c, 0.01 in CHCl3)
Solubility	Soluble in methanol, ethanol, DMSO and other organic solvents
Appearance	Light yellow to yellow (Solid)
Color	Yellow
pKa	4.50±1.00(Predicted)
Storage Condition	-20°C
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. Garcinol is prone to oxidation. Protect from exposure to air.
MDL	MFCD03700761

biological activity	Garcinol is a kind of polyisoprenyl benzophenone extracted from Garcinia indigotica, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) have anticholinesterase properties with IC50 of 0.66 μm and 7.39 μm, respectively. Garcinol also inhibited histone acetyltransferase (HATs, IC50 = 7 μm) and p300/CPB-related factors (PCAF, IC50 = 5 μm). Garcinol has anti-inflammatory and anti-cancer activity.
Cell Line:	CAL27 and UMSCC1 cells CAL27 and UMSCC1 cells CAL27 cells
Concentration:	10, 25, 50 µM 10, 25, 50 µM 50 µM
Incubation Time:	24, 48, and 72 hours 24, 48, and 72 hours 1, 2, 4, 6 hours
Result:	Inhibited the proliferation of two HNSCC cell lines in a time- and dose-dependent manner. Induced apoptosis in HNSCC cells. Suppressed phosphorylation and degradation of the constitutive IκBα in a time-dependent manner. Induced significant inhibition of tumor growth.
Animal Model:	Five-week-old athymic nu/nu male mice bearing subcutaneous CAL27 tumors
Dosage:	1 and 2 mg/kg
Administration:	I.p.; five times/week for 4 consecutive weeks

Last Update：2024-04-09 21:21:28

Product Name: Garcinol Visit Supplier Webpage Request for quotation
CAS: 78824-30-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

Product Name: Garcinol Visit Supplier Webpage Request for quotation
CAS: 78824-30-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

View History

78824-30-3

78824-30-3 Request for Quotation