78920-10-2

Name	2(5H)-FURANONE, 5-HYDROXY-4-PROPYL-
Synonyms	5-hydroxy-4-n-propylfuran-2-one 5-hydroxy-4-propylfuran-2(5H)-one 5-Hydroxy-4-propyl-2(5H)-furanone 5-Hydroxy-4-propyl-5H-furan-2-one 5-hydroxy-4-propyl-1H-furan-2-one 2-hydroxy-3-propyl-2H-furan-5-one 2(5H)-FURANONE, 5-HYDROXY-4-PROPYL- Benzeneaceticacid,5-hydroxy-,ethylester
CAS	78920-10-2
EINECS	821-451-7

Molecular Formula	C7H10O3
Molar Mass	142.15
Density	1.198±0.06 g/cm3(Predicted)
Boling Point	115 °C(Press: 0.01 Torr)
Solubility	Chloroform (Sparingly), Methanol (Slightly)
Vapor Presure	0.011-0.02Pa at 20-25℃
Appearance	Oil
Color	Yellow to Very Dark Brown
pKa	10.04±0.40(Predicted)
Storage Condition	2-8°C
Use	This product is for scientific research only and shall not be used for other purposes.

LogP	0.6 at 20℃ and pH6.4
surface tension	59.89mN/m at 1g/L and 20 ℃
Application	4-propyl-5-hydroxyfuran-2-one can be used as a pharmaceutical synthesis intermediate, if the following reaction occurs: a suitable amount of 18G (S)-2-aminobutyramide hydrochloride was mixed with 3.3 ml of ammonia in Isopropanol (3.7-moL/L). Free, then reacted with 19g of 4-propyl-5-hydroxyfuran-2-one at room temperature; 18.44G of solid product was obtained. The yield was 61.0%. Alternatively, an isopropanol solution containing 5-hydroxy-4-n-propyl-furan-2-one is slowly added dropwise to a solution of free (S)-2-aminobutanamide in isopropanol, the reaction was stirred magnetically overnight at room temperature, and the next step was carried out without treatment. ESI-MS(m/z):227[M H].
Use	4-propyl-5-hydroxyfuran-2-one can be used as a pharmaceutical synthesis intermediate, as in the preparation of the buvaracetam (Brivaracetam) intermediate. The chemical name of buvaracetam is (2S)-2-[(4R)-2-oxo-4-n-propylpyrrolidinyl] butanamide, which is a new type of antiepileptic drug developed by UCB in Belgium.

Last Update：2024-04-09 20:49:11