79427-88-6

Name	2-hydroxy-5-(trifluoromethyl)benzoic acid
Synonyms	UKRORGSYN-BB BBV-264038 2-Hydroxy-5-trifluoromethylbenzoic acid 5-Trifluoromethyl-2-hydroxybenzoic acid 2-Hydroxy-5-Trifluoromethyl Benzoic Acid 2-hydroxy-5-(trifluoromethyl)benzoic acid benzoic acid, 2-hydroxy-5-(trifluoromethyl)- Benzoic acid, 2-hydroxy-5-(trifluoromethyl)- 2-Carboxy-4-(trifluoromethyl)phenol, 3-Carboxy-4-hydroxybenzotrifluoride, 5-(Trifluoromethyl)salicylic acid
CAS	79427-88-6
InChI	InChI=1/C8H5F3O3/c9-8(10,11)4-1-2-6(12)5(3-4)7(13)14/h1-3,12H,(H,13,14)

Molecular Formula	C8H5F3O3
Molar Mass	206.12
Density	1.539±0.06 g/cm3(Predicted)
Boling Point	292.8±40.0 °C(Predicted)
Flash Point	130.857°C
Vapor Presure	0.001mmHg at 25°C
pKa	2.55±0.10(Predicted)
Storage Condition	Inert atmosphere,Room Temperature
Refractive Index	1.51
Use	An important pharmaceutical pesticide intermediate that enhances the absorption of antibiotic drugs and is used as an adjunct to suppositories and glutamate for the treatment of rectal cancer

Overview	2-hydroxy-5-trifluoromethylbenzoic acid is an organic intermediate, it can be prepared by reacting 2-methoxy-5-(trifluoromethyl) benzoic acid with iodocyclohexane.
preparation	2-methoxy-5-(trifluoromethyl) benzoic acid (5.00g,22.71mmol) place into a flask containing iodocyclohexane (29.4mL,227mmol) and DMF(25mL). The reaction mixture was refluxed for 4H, cooled and the solvent removed in vacuo. The crude product was purified by Silica Gel chromatography eluting with 0-100% EtOAc in ISO-hexane to give the title compound 2-hydroxy-5-trifluoromethylbenzoic acid. 1H NMR (8.29 MHz,CDCl3) Δ10.70 (1H,s),7.80(1H,d),7.15(1H,dd), (1H,d).
Use	an important intermediate of medicine and pesticide, which can enhance the absorption of antibiotic drugs, used as an adjuvant to treat rectal cancer suppositories and glutamate

Last Update：2024-04-09 02:00:02