8-Fluoro-2-azanaphthalene

8-Fluoro-2-azanaphthalene - Names and Identifiers

Name	8-Fluoroisoquinoline
Synonyms	8-Fluoroisoquinoline Isoquinoline, 8-fluoro- isoquinoline, 8-fluoro- 8-Fluoro-2-azanaphthalene
CAS	1075-00-9
InChI	InChI=1/C9H6FN/c10-9-3-1-2-7-4-5-11-6-8(7)9/h1-6H

8-Fluoro-2-azanaphthalene - Physico-chemical Properties

Molecular Formula	C9H6FN
Molar Mass	147.15
Density	1.216±0.06 g/cm3(Predicted)
Boling Point	255.3±13.0 °C(Predicted)
Flash Point	108.2°C
Vapor Presure	0.0264mmHg at 25°C
pKa	4.82±0.23(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.614

8-Fluoro-2-azanaphthalene - Risk and Safety

Hazard Symbols

Xi - Irritant

8-Fluoro-2-azanaphthalene - Introduction

8-fluoroisoquinoline is also known as 8-fluoroquinoline or 8-fluoroquinoxaline. The chemical formula is C9H5FNO, and its physical and chemical properties are as follows:

1. Physical properties:
-Appearance: Colorless crystalline solid.
-Melting point: 56-57 ℃.
-Boiling point: 216-220 ℃.
-Density: 1.35g/cm³.
-Solubility: Soluble in ethanol, ether, dimethyl sulfoxide and dichloromethane.

2. chemical properties:
-8-fluoroisoquinoline has a structure similar to quinoline and is an aromatic ketone.
-It can undergo electrophilic substitution reaction, and react with electrophilic reagents such as silver nitrate to generate corresponding substitution products.

3. use:
-Due to the stability and reactivity of 8-fluoroisoquinoline in organic synthesis, it is often used as a synthetic intermediate to participate in the preparation of a variety of target compounds.
-It can also be used to prepare biologically active molecules and has potential applications in the field of drug development.

4. Preparation method:
-Generally, 8-fluoroisoquinoline is prepared by reacting quinoline compounds with a fluorinating reagent. The reaction can be carried out under illumination.

5. Safety Information:
-Since 8-fluoroisoquinoline is used in organic synthesis, it is necessary to pay attention to its toxicity and danger.
-During operation, you need to follow appropriate laboratory safety procedures and wear personal protective equipment, such as gloves and safety glasses.
-During storage and handling, care should be taken to avoid contact with combustible substances and oxidants, and the container should be properly sealed and stored in a cool and dry place.

Last Update：2024-04-09 21:04:16