8-Formyl-4-methylumbelliferone
8-Formyl-4-methylumbelliferone
CAS: 14003-96-4
Molecular Formula: C11H8O4
8-Formyl-4-methylumbelliferone - Names and Identifiers
8-Formyl-4-methylumbelliferone - Physico-chemical Properties
| Molecular Formula | C11H8O4 |
| Molar Mass | 204.18 |
| Density | 1.541 |
| Melting Point | 189-190℃ (ethanol ) |
| Boling Point | 398.3±42.0 °C(Predicted) |
| Solubility | DMSO: soluble5mg/mL, clear (warmed) |
| Appearance | Yellow powder |
| Color | white to beige |
| pKa | 6.22±0.20(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| Refractive Index | 1.641 |
| In vitro study | 4μ8C blocks substrate (RIDD) access to the active site of IRE1 and selectively inactivates Xbp1 splicing and ire1-mediated mRNA degradation. Inhibition of IRE1 subsequently induces endoplasmic reticulum stress without measurable acute toxicity. 4μ8c, as an IRE1 inhibitor, blocks the production of IL-4,IL-5, and IL-13 in CD4 T cells. |
8-Formyl-4-methylumbelliferone - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| WGK Germany | 3 |
8-Formyl-4-methylumbelliferone - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 4.898 ml | 24.488 ml | 48.976 ml |
| 5 mM | 0.98 ml | 4.898 ml | 9.795 ml |
| 10 mM | 0.49 ml | 2.449 ml | 4.898 ml |
| 5 mM | 0.098 ml | 0.49 ml | 0.98 ml |
Last Update：2024-01-02 23:10:35
8-Formyl-4-methylumbelliferone - Reference Information
| biological activity | 4 μ8c is a highly potent and selective inhibitor of IRE1 Rnase with an IC50 of 76 nM. 4 μ8c (IRE1 Inhibitor III) is a highly potent and selective Inhibitor of IRE1 Rnase with an IC50 of 76 nM. |
| characteristics | IRE1 Rnase selective inhibitors as a platform for the development of new locally acting drugs. |
| Target | Value |
| IRE1 Rnase (Cell-free assay) | 76 nM |
Last Update：2024-04-09 21:04:16
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Spot supply
Product Name: 8-Formyl-4-methylumbelliferone Visit Supplier Webpage Request for quotationCAS: 14003-96-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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