8-Hydroxy-2-(di-n-propylamino)tetralin
S(-)-8-HYDROXY-DPAT HYDROBROMIDE PARTIAL 5-HT1A SECROT
CAS: 78950-78-4
Molecular Formula: C16H25NO
8-Hydroxy-2-(di-n-propylamino)tetralin - Names and Identifiers
8-Hydroxy-2-(di-n-propylamino)tetralin - Physico-chemical Properties
| Molecular Formula | C16H25NO |
| Molar Mass | 247.38 |
| Appearance | solid |
| Color | white |
| Storage Condition | -20℃ |
| In vitro study | 8-OH-DPAT is a potent and selective 5-HT agonist, with a pIC 50 of 8.19 for 5-HT1A; weakly binds to 5-HT1B (pIC 50 , 5.42), 5-HT (pIC 50 <5). 8-OH-DPAT has high affinity at 5-HT7 with a K i of 466 nM, and does not bind to 5-HT6 or 5-HT4. |
| In vivo study | 8-OH-DPAT (1 mg/kg) normalizes hypolocomotion, significantly increases wakefulness and reduces the duration of REM sleep without effect on the duration of non-REM sleep in the dark period in orexin knockout (KO) mice. 8-OH-DPAT shows no obvious effect on wakefulness or the duration of either REM sleep or non-REM sleep in WT mice. 8-OH-DPAT (1 mg/kg, s.c.) activates 5-HT1A receptor in orexin knockout mice. |
8-Hydroxy-2-(di-n-propylamino)tetralin - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
8-Hydroxy-2-(di-n-propylamino)tetralin - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.046 ml | 15.231 ml | 30.461 ml |
| 5 mM | 0.609 ml | 3.046 ml | 6.092 ml |
| 10 mM | 0.305 ml | 1.523 ml | 3.046 ml |
| 5 mM | 0.061 ml | 0.305 ml | 0.609 ml |
Last Update：2024-01-02 23:10:35
8-Hydroxy-2-(di-n-propylamino)tetralin - Reference Information
| biological activity | 8-OH-DPAT is a potent, selective 5-HT agonist with a pIC50 value of 8.19 for 5-HT1A, ki value for 5-HT7 is 466 nM, for 5-HT1B (pIC50, 5.42) and 5-HT (pIC50 |
Last Update：2024-04-09 02:00:14
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Spot supply
Product Name: S(-)-8-HYDROXY-DPAT HYDROBROMIDE PARTIAL 5-HT1A SECROT Visit Supplier Webpage Request for quotationCAS: 78950-78-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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