8-chloro-N-(4-(trifluoromethoxy)phenyl)quinolin-2-amine
8-chloro-N-(4-(trifluoromethoxy)phenyl)quinolin-2-amine
CAS: 1258453-75-6
Molecular Formula: C16H10ClF3N2O
8-chloro-N-(4-(trifluoromethoxy)phenyl)quinolin-2-amine - Names and Identifiers
8-chloro-N-(4-(trifluoromethoxy)phenyl)quinolin-2-amine - Physico-chemical Properties
| Molecular Formula | C16H10ClF3N2O |
| Molar Mass | 338.71 |
| Density | 1.440±0.06 g/cm3(Predicted) |
| Boling Point | 412.3±45.0 °C(Predicted) |
| Solubility | DMSO : 100 mg/mL (295.24 mM) |
| pKa | 1.50±0.61(Predicted) |
| Storage Condition | -20°C |
| Use | Obefazimod (ABX464) is an effective anti-HIV agent. Obefazimod acts on stimulated peripheral blood mononuclear cells (PBMCs) to inhibit HIV-1 replication with an IC50 of 0.1 μM to 0.5 μM. |
| Target | HIV-1 |
8-chloro-N-(4-(trifluoromethoxy)phenyl)quinolin-2-amine - Reference
| Reference Show more | 1: Pai S, Mudgal J, Kamath BV, Pai KSR. An insight on promising strategies hoping to cure HIV-1 infection by targeting Rev protein-short review. Pharmacol Rep. 2021 Apr 11. doi: 10.1007/s43440-021-00257-9. Epub ahead of print. PMID: 33840054. 2: Vermeire S, Hébuterne X, Tilg H, De Hertogh G, Gineste P, Steens JM; ABX464 Investigators. Induction and Long-term Follow-up With ABX464 for Moderate-to- severe Ulcerative Colitis: Results of Phase IIa Trial. Gastroenterology. 2021 Jun;160(7):2595-2598.e3. doi: 10.1053/j.gastro.2021.02.054. Epub 2021 Mar 2. PMID: 33662385. 3: Tazi J, Begon-Pescia C, Campos N, Apolit C, Garcel A, Scherrer D. Specific and selective induction of miR-124 in immune cells by the quinoline ABX46 4: a transformative therapy for inflammatory diseases. Drug Discov Today. 2021 Apr;26(4):1030-1039. doi: 10.1016/j.drudis.2020.12.019. Epub 2020 Dec 30. PMID: 33387693. 4: Rutsaert S, Steens JM, Gineste P, Cole B, Kint S, Barrett PN, Tazi J, Scherrer D, Ehrlich HJ, Vandekerckhove L. Safety, tolerability and impact on viral reservoirs of the addition to antiretroviral therapy of ABX464, an investigational antiviral drug, in individuals living with HIV-1: a Phase IIa randomised controlled study. J Virus Erad. 2019 Jan 1;5(1):10-22. PMID: 30800421; PMCID: PMC6362909. 5: Vautrin A, Manchon L, Garcel A, Campos N, Lapasset L, Laaref AM, Bruno R, Gislard M, Dubois E, Scherrer D, Ehrlich JH, Tazi J. Both anti-inflammatory and antiviral properties of novel drug candidate ABX464 are mediat |
8-chloro-N-(4-(trifluoromethoxy)phenyl)quinolin-2-amine - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.952 ml | 14.762 ml | 29.524 ml |
| 5 mM | 0.59 ml | 2.952 ml | 5.905 ml |
| 10 mM | 0.295 ml | 1.476 ml | 2.952 ml |
| 5 mM | 0.059 ml | 0.295 ml | 0.59 ml |
Last Update：2024-01-02 23:10:35
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