80352-42-7

80352-42-7 - Names and Identifiers

Name	4-Bromophenylglyoxal hydrate
Synonyms	4-Bromophenylglyoxal 4-Bromophenylglyoxal hydrate 4-BROMOPHENYLGLYOXAL HYDRATE 1-(4-bromophenyl)-2,2-dihydroxyethanone 1-(4-Bromophenyl)-2,2-dihydroxyethanone (4-Bromophenyl)(oxo)acetaldehyde hydrate Ethanone, 1-(4-bromophenyl)-2,2-dihydroxy-
CAS	80352-42-7
InChI	InChI=1/C8H7BrO3/c9-6-3-1-5(2-4-6)7(10)8(11)12/h1-4,8,11-12H

80352-42-7 - Physico-chemical Properties

Molecular Formula	C8H7BrO3
Molar Mass	231.04
Density	1.743±0.06 g/cm3(Predicted)
Melting Point	132°C
Boling Point	340.0±32.0 °C(Predicted)
Flash Point	159.4°C
Vapor Presure	3.42E-05mmHg at 25°C
pKa	10.42±0.41(Predicted)
Storage Condition	2-8°C
Refractive Index	1.627

80352-42-7 - Risk and Safety

Hazard Symbols	Xi - Irritant
Hazard Note	Irritant

80352-42-7 - Reference Information

Application

4-bromophenyl glyoxal hydrate can be used as an intermediate in pharmaceutical synthesis, which can be prepared by reacting with selenium dioxide from 4-bromophenyl ketone.

preparation

SeO2(1390mg,1.25mmol) is suspended in a mixture of 1,4-dioxane (6mL) and H2O(0.4mL), and 4-bromophenyl ketone (5.0mmol) is added for microwave radiation, hold time (15 minutes) at the set temperature of 100°C. The solution is then cooled to room temperature, the solution is filtered to remove Se, and washed with MeOH(20mL), the combined organic filtrate is concentrated under reduced pressure, then the organic residue is stirred in boiling H2O(35mL), and hot filtered to remove any insoluble precipitate. The aqueous filtrate was cooled on ice to obtain crystals of aryl glyoxal monohydrate product, collected under vacuum filtration, washed with cold H2O, and dried in a vacuum dryer to obtain 4-bromophenyl glyoxal hydrate, white powder (82%).

Last Update：2024-04-09 01:59:59