80418-24-2
netoginsenoside R1
CAS: 80418-24-2
Molecular Formula: C47H80O18
80418-24-2 - Names and Identifiers
80418-24-2 - Physico-chemical Properties
| Molecular Formula | C47H80O18 |
| Molar Mass | 933.14 |
| Density | 1.39±0.1 g/cm3(Predicted) |
| Melting Point | 215～217℃ |
| Boling Point | 1010.5±65.0 °C(Predicted) |
| Specific Rotation(α) | (c, 1.0 in MeOH)+15 |
| Flash Point | 564.9°C |
| Solubility | DMSO : ≥ 100 mg/mL (107.17 mM) |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | White powder |
| Color | white to off-white |
| pKa | 12.85±0.70(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Sensitive | Easily absorbing moisture |
| Refractive Index | 1.614 |
| MDL | MFCD00210535 |
| Physical and Chemical Properties | Dried roots of Panax from araliaceae |
80418-24-2 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29389090 |
80418-24-2 - Reference Information
| Plant Source: | Panax notoginseng |
| Overview | notoginsenoside R1 is derived from Panax notoginseng panaxnotoginsen (Burk.)F.H.Chen's dried roots and rhizomes, function to dissipate blood stasis and stop bleeding, detumescence and pain. Panax notoginseng is the root of Panax notoginseng (Burk.)F.H.Chen, a plant of the family Araliaceae, which has the effects of dispersing blood stasis, stopping bleeding, relieving swelling and fixing pain. Modern pharmacological studies have shown that Panax notoginseng has the effects of delaying aging, expanding blood vessels and improving microcirculation. The main active ingredient in Panax notoginseng is Panax NotoginsengSaponins (PNS), including a variety of monomeric glycosides, which can promote blood circulation and improve energy metabolism. Notoginsenoside Rl (NTRl). |
| extraction of medicinal herbs and preparation of reference solution | extraction of medicinal herbs: precision weighing this product powder (through No. 4 sieve) 0.5678g, precision add methanol 50ml, weigh, overnight, 80 ℃ water bath to maintain micro-boiling for 2 hours, cool, weigh again, use methanol to make up the lost weight, shake, filter, and take the filtrate. preparation of reference solution: precision weighing ginsenoside Rgl control, ginsenoside Rbl control and notoginsenoside R1 control 14.7mg,13.2mg and 8.0mg respectively, add methanol to a 10ml volumetric flask to dissolve and dilute to the scale, and shake; Take the above three kinds of reference substances and mobile phase to make a mixed solution containing ginsenoside rg10.18 mg, ginsenoside rb10.16 mg, notoginsenoside r10.10 mg per 1ml. |
| Analysis conditions | column: AgilentZorbaxSB-C18 150x 4.6mm,5ym injection volume: 20yl detection wavelength: 203nm column temperature: 25.0 ℃ mobile phase: 0-12mm acetonitrile: Water = 19:81,12-60min acetonitrile: water =(19 a 36):(81~64) Method Source: "Chinese Pharmacopoeia" 2005 edition control content: ginsenoside Rg 199.0%, ginsenoside Rb 199.4%, notoginsenoside R 199.0% instrument; Agilent 1200 configuration: Quaternary gradient pump (with vacuum degassing),DAD detector, column oven, automatic sampler. analysis results The total content of ginsenoside Rg1, ginsenoside Rb1 and notoginsenoside R1 in the control medicinal materials calculated by external standard method was 9-31%, for ginsenoside Rb1 and notoginsenoside R1, the tailing factor was 0.98, 1.07 and 0.98, and the number of column theoretical plates was 3321, 3840 and 2987, respectively. |
| separation and purification | in order to obtain relatively pure notoginsenoside R1, the total saponins of Panax notoginseng were extracted from radix notoginseng by methanol extraction, then macroporous adsorption resin-silica gel column chromatography was used to separate Panax notoginseng saponins in two steps, and notoginsenoside R1 monomer was obtained. The results showed that 82.0g of Panax notoginseng saponins could be obtained in 1 000 g of radix notoginseng, and the extraction rate was 8.20%. 80.0g of Panax notoginseng saponins were adsorbed on AB-8 macroporous adsorption resin column and eluted with 36% ethanol to obtain 40.0g of saponins containing notoginsenoside R1; 40.0g of saponin component containing notoginsenoside R1 was further separated by silica gel column chromatography, 1.27g of relatively pure notoginsenoside R1 was obtained, the yield was 1.55%, and the monomer purity was 98.48% by HPLC. fig.1 HPLC chromatogram of notoginsenoside R1 |
| Use | the present invention proves that NTR1 can improve the cognitive, learning and memory abilities of APP/PS1 transgenic AD mice through experiments, restore the level of ChAT in the brain, reduce the level of MDA in the brain, and improve the mitochondrial function of AD mice by increasing the activity of CcO. Moreover, NTR1 can also increase the level of IDE, thereby promoting the degradation of Aβ and inhibiting the accumulation of Aβ. Therefore, the present invention further provides the use of notoginsenoside R1 in the preparation of a medicament for the treatment of Alzheimer's disease. It was confirmed that notoginsenoside R1 had no effect on cell viability in the concentration range of 0 μmol/L ~ 500 μmol/L. The safety of the drug was explained. 1. Improving microcirculation and protecting cardiovascular function: in the 90 s, NTRl has been studied to improve the mechanism of cardiovascular disease. NTRl promotes the synthesis of the fibrinolytic system in a variety of vascular-associated cells; the mechanism of action may be through inhibition of E-selectin expression in endothelial cells and neutrophil CD18 protein expression. Another study showed that NTRl can inhibit TNF-a-induced venous endothelial cell fibronectin levels and cell migration at the cellular level by inhibiting ERK activation and NADPH oxidase-mediated ROS production. 2. Anti-inflammatory effect: NTRl injected into the tail vein can reduce the death of mice caused by lipopolysaccharide (LPS). NTRl also inhibited TNF-a of the LPS-induced elevation in human whole blood cell cultures. The latest study found that NTRl can inhibit the inflammatory factors of NF-kappa B pathway in the mouse model of cardiac dysfunction induced by lipopolysaccharide, and reduce the inflammatory response and apoptosis of myocardium. This effect may be through up-regulation of estrogen receptor a (ERa) and PI3K/Akt pathway. 3. Other effects: NTR1 also has some anti-tumor and anti-oxidation effects. for content determination/identification/pharmacological experiments. Pharmacological Efficacy: blood circulation effect. notoginsenoside R1 is the main active ingredient of Panax notoginseng, which is reported to have neuroprotective and antihypertensive effects. |
| reference material | [1] notoginsenoside R1. National standard material network. 2010-5-12 [reference date 2013-01-4] [2] Panax notoginseng. National standard material network. 2013-1-1 [citation date 2013-01-4] [3] Zhang Wensheng, Li Zhi. Application of notoginsenoside R1 [P]. Beijing: CN103877107A,2014-06-25. [4] Zhang Yan, Song Jianguo, fish red flash, Jin fengxie. Separation and Purification of notoginsenoside R_1 [J]. Journal of Dalian Polytechnic University, 2011,30(03):161-164. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 21:00:56
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Email: 2853786052@qq.com
Mobile: 86+15671228036
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