80506-64-5
Methoxypolyethylene glycol amine
CAS: 80506-64-5
Molecular Formula: H2NCH2CH2(OCH2CH2)nOCH3
80506-64-5 - Names and Identifiers
| Name | Methoxypolyethylene glycol amine |
| Synonyms | Methoxypolyethylene glycol amine Poly(ethylene glycol) α-2-aMinoethyl, ω-Methoxy |
| CAS | 80506-64-5 |
80506-64-5 - Physico-chemical Properties
| Molecular Formula | H2NCH2CH2(OCH2CH2)nOCH3 |
| Molar Mass | 119.16222 |
| Melting Point | 58-61 °C(lit.) |
| Flash Point | >110℃ |
| Water Solubility | Soluble in water. |
| Solubility | Chloroform (Slightly), MEtanol (Slightly) |
| Appearance | Morphological Granular Solid |
| Color | White to off-white |
| Storage Condition | 2-8°C |
| Sensitive | Sensitive to air |
| MDL | MFCD00131599 |
| Use | Use Methoxypolyethylene glycol amine can be used as PEG modifier, which is a soluble polymer and is used to support the synthesis of polypeptides. Preparation of various combinations containing polyethylene glycol. |
80506-64-5 - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 2-9 |
| TSCA | Yes |
| HS Code | 39072090 |
80506-64-5 - Uses and synthesis methods
overview
methoxypolyethylene glycol amine is an important type of modified polyethylene glycol. modified PEG is also called modified polyethylene glycol, which is modified by chemically modified groups or bioactive groups.
application
Methoxypolyethylene glycol amine has the following applications: 1. Corrosion-resistant coating materials for military sensors; 2. Prodrug of oridonin with polyethylene glycol as a carrier.
Preparation
1. Preparation of methoxypolyethylene glycol amine 2000
dissolve 2g of monomethoxypolyethylene glycol azide 2000 in 20mL of dry tetrahydrofuran, then add 0.2g of 10% palladium and carbon, replace the air in the reaction bottle with hydrogen, react at 25 ℃ for 24 hours, and the reaction is complete. Removal of palladium and carbon by suction filtration, evaporation of solvent under reduced pressure, purification with anhydrous ether beating to obtain 1.8g product with a yield of 90.14%.
2. Preparation of methoxypolyethylene glycol azide 1000
Under the protection of nitrogen, 1.0g of monomethoxypolyethylene glycol 1000 and 0.53g of triphenylphosphorus. 0.56g of diphenyl azidophosphate is dissolved in 10mL of dry dichloromethane, the reaction bottle is placed in a low temperature environment of 0 ℃ and stirred for a certain period of time until the temperature in the reaction bottle is lower than 5 ℃, then 0.4g of diisopropyl azodicarboxylate is slowly added dropwise, and the temperature is kept below 15 ℃ during the dropwise process. After dropping, the reaction system gradually changed from turbid to clear, and the color changed from light yellow to golden yellow. After 3 hours of reaction, the reaction was complete, and the volume was evaporated under reduced pressure to obtain yellow oil. The yield of 0.86g of the product was 83.25%.
Last Update：2024-04-10 22:41:56
80506-64-5 - Nature
| EPA chemical information | Poly(oxy-1,2-ethanediyl), .alpha.-(2-aminoethyl)-.omega.-methoxy- (80506-64-5) |
Last Update：2024-04-09 21:04:16
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