805239-56-9
4-[2-PHENYL-5,7-BIS(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL]PHENOL
CAS: 805239-56-9
Molecular Formula: C20H11F6N3O
805239-56-9 - Names and Identifiers
805239-56-9 - Physico-chemical Properties
| Molecular Formula | C20H11F6N3O |
| Molar Mass | 423.31 |
| Appearance | powder |
| Color | yellow to orange |
| Storage Condition | 2-8°C |
| In vitro study | PHTPP is a selective ERβ antagonist. PHTPP reduces FSH-mediated cAMP production by 80% (p<0.01) while it has no effect on basal cAMP. PHTPP (10 -6 M) inhibits E2-stimulated ERβ activity, but does not suppress E2-stimulated ERα activity. A high dose of PHTPP (10 -6 M) slightly increases class 1 Igf1 mRNA expression, and facilitates the DPN-induced increase in class 1 Igf1 mRNA expression. |
805239-56-9 - Risk and Safety
| UN IDs | UN 2811 6.1 / PGIII |
805239-56-9 - Reference
| Reference Show more | 1. [IF=4.285] Li Pan et al."ESR1 mediates estrogen-induced feminization of genetic male Chinese soft-shelled turtle."BIOLOGY OF REPRODUCTION. 2022 May;: |
805239-56-9 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.362 ml | 11.812 ml | 23.623 ml |
| 5 mM | 0.472 ml | 2.362 ml | 4.725 ml |
| 10 mM | 0.236 ml | 1.181 ml | 2.362 ml |
| 5 mM | 0.047 ml | 0.236 ml | 0.472 ml |
Last Update：2024-01-02 23:10:35
805239-56-9 - Reference Information
| biological activity | PHTPP is a selective estrogen receptor beta (ERβ) antagonist, its selectivity is 36 times that of ERα. |
| Target | ERβ |
| in vitro study | phtpis a selective ER β-angionist. PHTPP reductions FSH-mediated cAMP production by 80% (p<0.01) while it has no effect on basal cAMP. PHTPP (10 -6 M) inhibit E2-stimulated ERβ activity, but does not suppress E2-stimulated ERα activity. A high dose of PHTPP (10 -6 M) slightly increases class 1 Igf1 mRNA expression, and facilitates the DPN-induced increase in class 1 Igf1 mRNA expression. |
Last Update：2024-04-09 21:11:58
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Product Name: 4-[2-PHENYL-5,7-BIS(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL]PHENOL Visit Supplier Webpage Request for quotationCAS: 805239-56-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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