808118-40-3
FG-4592
CAS: 808118-40-3
Molecular Formula: C19H16N2O5
808118-40-3 - Names and Identifiers
| Name | FG-4592 |
| Synonyms | FG-4592 FG-4592(ASP1517) N-[(4-Hydroxy-1-Methyl-7-phenoxy-3-isoquinolinyl)carbonyl]glycine N-[(4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]glycine Glycine, N-[(4-hydroxy-1-Methyl-7-phenoxy-3-isoquinolinyl)carbonyl]- Glycine, N-[(4-hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]- 2-(4-hydroxy-1-Methyl-7-phenoxyisoquinoline-3-carboxaMido)acetic acid 2-(4-HYDROXY-1-METHYL-7-PHENOXYISOQUINOLINE-3-CARBOXAMIDO)ACETIC ACID [[(4-Hydroxy-1-Methyl-7-phenoxyisoquinolin-3-yl)carbonyl]aMino]acetic Acid [[(4-Hydroxy-1-methyl-7-phenoxyisoquinolin-3-yl)carbonyl]amino]acetic acid |
| CAS | 808118-40-3 |
| EINECS | 813-400-2 |
| InChI | InChI=1S/C19H16N2O5/c1-11-15-9-13(26-12-5-3-2-4-6-12)7-8-14(15)18(24)17(21-11)19(25)20-10-16(22)23/h2-9,24H,10H2,1H3,(H,20,25)(H,22,23) |
808118-40-3 - Physico-chemical Properties
| Molecular Formula | C19H16N2O5 |
| Molar Mass | 352.34 |
| Density | 1.389 |
| Melting Point | 199-215°C |
| Boling Point | 684.3±55.0 °C(Predicted) |
| Solubility | DMSO >70 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
| Appearance | solid |
| Color | Off-white or white |
| pKa | 2.46±0.10(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
| In vitro study | FG-4592, an oral hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor, is used clinically to treat anemia. FG-4592 stabilizes the activity of HIF, an intracellular transcription factor that leads to the activation of genes associated with red blood cells, including EPO, and enzymes involved in iron metabolism. |
808118-40-3 - Introduction
FG-4592 is a HIFαprolyl hydroxylase inhibitor, and can stabilize HIF-2 and induce EPO production.
Last Update：2022-10-16 17:29:05
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Product Name: FG-4592 Visit Supplier Webpage Request for quotationCAS: 808118-40-3
Tel: 18301782025
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Mobile: 18021002903
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QQ: 2965663228Send QQ message
CAS: 808118-40-3
Tel: 021-60290089
Email: dshs21@eagle-pharm.com
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