81449-93-6

81449-93-6 - Names and Identifiers

Name	Ethyl 2-chlorothiazole-5-carboxylate
Synonyms	Ethyl 2-chlorothiazole-5-carboxylate Ethyl 2-chloro-5-thiazolecarboxylate ETHYL 2-CHLOROTHIAZOLE-5-CARBOXYLATE ethyl 2-chloro-1,3-thiazole-5-carboxylate 2-Chlorothiazole-5-carboxylic acid ethyl ester 2-Chloro-5-thiazolecarboxylic acid ethyl ester 5-Thiazolecarboxylicacid, 2-chloro-, ethyl ester
CAS	81449-93-6
InChI	InChI=1/C6H6ClNO2S/c1-2-10-5(9)4-3-8-6(7)11-4/h3H,2H2,1H3

81449-93-6 - Physico-chemical Properties

Molecular Formula	C6H6ClNO2S
Molar Mass	191.64
Density	1.383±0.06 g/cm3(Predicted)
Boling Point	283.9±32.0 °C(Predicted)
Flash Point	125.5°C
Solubility	Chloroform; Dichloromethane; DMSO; Ethyl Acetate
Vapor Presure	0.00307mmHg at 25°C
Appearance	Oil
Color	Colorless
pKa	-0.98±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index	1.548

81449-93-6 - Introduction

Ethyl, also known as Ethyl, is an organic compound. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance: colorless or yellowish liquid
-Molecular formula: C7H7ClN2O2S
-Molecular weight: 214.66g/mol
-Melting point: 26-28 degrees Celsius
-Boiling point: 264-266 degrees Celsius
-Good stability at room temperature, but decomposition may occur when encountering high temperatures, strong oxidants and strong acids.

Use:
Ethyl is often used in organic synthesis as an important intermediate. It can be used to synthesize other compounds containing thiazole ring, such as thiazole antibacterial drugs, pesticides and photosensitive materials.

Preparation Method:
Ethyl was prepared as follows:
1. first, at a lower temperature, in the presence of sodium thiazole hydrogen (sodium hydrosulfide) and 2-chloroethyl acetate (Ethyl 2-chloroacetate), the reaction was obtained Ethyl 'diene intermediate.
2. Then, the diene intermediate is converted to Ethyl by a dehydrochlorination reaction (such as in the presence of sodium methoxide).

Safety Information:
- Ethyl may cause irritation to the skin, eyes and mucous membranes. Be careful when touching it.
-Wear appropriate protective equipment including goggles, gloves and protective clothing when using or handling the compound.
-Avoid contact with strong oxidants and strong acids during storage and handling.
-When using this compound, comply with relevant hygiene and safety regulations and avoid inhaling its vapor or dust. In case of discomfort or accident, seek medical attention immediately.

Last Update：2024-04-09 21:01:54