81740-18-3
tert-butyl (3-fluorophenyl)carbamate
CAS: 81740-18-3
Molecular Formula: C11H14FNO2
81740-18-3 - Names and Identifiers
| Name | tert-butyl (3-fluorophenyl)carbamate |
| Synonyms | 106769 N-Boc-3-fluoroaniline 1-N-Boc-3-Fluoro-Aniline 3-Fluoroaniline, N-BOC protected tert-butyl (3-fluorophenyl)carbamate tert-Butyl (3-fluorophenyl)carbamate N-(tert-Butoxycarbonyl)-3-fluoroaniline N-(tert-butyloxycarbonyl)-Meta-fluoroaniline Carbamic acid, N-(3-fluorophenyl)-, 1,1-dimethylethyl ester |
| CAS | 81740-18-3 |
| InChI | InChI=1/C11H14FNO2/c1-11(2,3)15-10(14)13-9-6-4-5-8(12)7-9/h4-7H,1-3H3,(H,13,14) |
81740-18-3 - Physico-chemical Properties
| Molecular Formula | C11H14FNO2 |
| Molar Mass | 211.23 |
| Density | 1.156±0.06 g/cm3(Predicted) |
| Melting Point | 123-124℃ |
| Boling Point | 231.6±23.0 °C(Predicted) |
| Flash Point | 93.9°C |
| Vapor Presure | 0.0619mmHg at 25°C |
| pKa | 13.08±0.70(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.526 |
81740-18-3 - Introduction
tert-butyl (3-fluorophenyl)carbamate, the chemical name is tert-butyl (3-fluorophenyl)carbamate, is an organic compound. The following is a detailed description of the properties, uses, preparation methods and some safety information of the compound:
Nature:
-Appearance: White solid
-Molecular formula: C11H14FNO2
-Molecular weight: 217.23g/mol
-Melting point: 80-82 degrees Celsius
-Boiling point: about 282-283 degrees Celsius
-Solubility: Soluble in some organic solvents such as dimethylformamide (DMF), dichloromethane
Use:
tert-butyl (3-fluorophenyl) is carbamate commonly used in the field of organic synthesis, mainly used as an intermediate or starting material. For example, the compound can be used to synthesize organic compounds such as pharmaceuticals, pesticides, dyes, etc. In addition, tert-butyl (3-fluorophenyl)carbamate can also be used as a protecting group in organic synthesis reactions.
Preparation Method:
The preparation of tert-butyl (3-fluorophenyl)carbamate generally includes the following steps:
1. 3-fluoroaniline is reacted with dimethylformamide to prepare the N-Boc protected derivative of 3-fluoroaniline.
2. The product obtained in the previous step is reacted with tert-butanol to generate tert-butyl (3-fluorophenyl)carbamate.
Safety Information:
The use of tert-butyl (3-fluorophenyl)carbamate requires compliance with the safe operation of chemical laboratories. It may be irritating to the eyes, skin and respiratory tract, so it is necessary to wear appropriate personal protective equipment, such as protective glasses, gloves and respiratory protection equipment. During operation and storage, avoid contact with oxidants to prevent fire and explosion. In addition, the compound should be stored properly, away from fire and high temperature environment.
Nature:
-Appearance: White solid
-Molecular formula: C11H14FNO2
-Molecular weight: 217.23g/mol
-Melting point: 80-82 degrees Celsius
-Boiling point: about 282-283 degrees Celsius
-Solubility: Soluble in some organic solvents such as dimethylformamide (DMF), dichloromethane
Use:
tert-butyl (3-fluorophenyl) is carbamate commonly used in the field of organic synthesis, mainly used as an intermediate or starting material. For example, the compound can be used to synthesize organic compounds such as pharmaceuticals, pesticides, dyes, etc. In addition, tert-butyl (3-fluorophenyl)carbamate can also be used as a protecting group in organic synthesis reactions.
Preparation Method:
The preparation of tert-butyl (3-fluorophenyl)carbamate generally includes the following steps:
1. 3-fluoroaniline is reacted with dimethylformamide to prepare the N-Boc protected derivative of 3-fluoroaniline.
2. The product obtained in the previous step is reacted with tert-butanol to generate tert-butyl (3-fluorophenyl)carbamate.
Safety Information:
The use of tert-butyl (3-fluorophenyl)carbamate requires compliance with the safe operation of chemical laboratories. It may be irritating to the eyes, skin and respiratory tract, so it is necessary to wear appropriate personal protective equipment, such as protective glasses, gloves and respiratory protection equipment. During operation and storage, avoid contact with oxidants to prevent fire and explosion. In addition, the compound should be stored properly, away from fire and high temperature environment.
Last Update：2024-04-09 20:52:54
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