82-89-3
PRODIGIOSIN
CAS: 82-89-3
Molecular Formula: C20H25N3O
82-89-3 - Names and Identifiers
| Name | PRODIGIOSIN |
| Synonyms | PRODIGIOSIN Prodigiosine 4-Methoxy-5-[(5-methyl-4-pentyl-2H-pyrrol-2-ylidene)methyl], 2,2'bipyrrole 4-Methoxy-5-(4-pentyl-5-methyl-2H-pyrrole-2-ylidenemethyl)-2,2'-bi[1H-pyrrole] 4-Methoxy-5-[(5-methyl-4-pentyl-2H-pyrrol-2-ylidene)methyl]-2,2'-bi[1H-pyrrol] 4-Methoxy-5-[(5-methyl-4-pentyl-2H-pyrrol-2-ylidene)methyl]-2,2'-bi[1H-pyrrole] (Z)-4-Methoxy-5-((5-Methyl-4-pentyl-2H-pyrrol-2-ylidene)Methyl)-1H,1'H-2,2'-bipyrrole 3-Methoxy-2-(5-methyl-4-pentyl-2H-pyrrol-2-ylidene)methyl-5-(1H-pyrrol-2-yl)-1H-pyrrole |
| CAS | 82-89-3 |
82-89-3 - Physico-chemical Properties
| Molecular Formula | C20H25N3O |
| Molar Mass | 323.43 |
| Density | 1.12±0.1 g/cm3(Predicted) |
| Melting Point | 151-152° |
| Boling Point | 554.3±50.0 °C(Predicted) |
| Solubility | Insuluble (5.8E-3 g/L) (25 °C) |
| Appearance | Light brown to reddish brown (Solid) |
| pKa | 17.09±0.50(Predicted) |
| Storage Condition | -20C |
82-89-3 - Reference Information
| biological activity | Prodigiosine, a natural red pigment, it is a secondary metabolite with biological activity. Prodigiosin is a potent inhibitor of the Wnt/β-catenin pathway. Prodigiosin has antibacterial, antifungal, antiprotozoal, antimalarial, immunosuppressive and anticancer properties. |
| Cell Line: | MDA-MB-231 and MDA-MB-468 cells HEK293T cells |
| Concentration: | 10 nM, 25 nM, 50 nM, 100 nM, 250 nM, 500 nM, 1000 nM, 2500 nM, 5000 nM 50 nM, 100 nM, 250 nM, 500 nM |
| Incubation Time: | 24 hours, 48 hours 24 hours |
| Result: | Reduced the viability of breast cancer cells, with IC 50 values at 48 h of 62.52 nM in MDA-MB-231 cells and 261.2 nM in MDA-MB-468 cells. Significantly reduced the levels of phosphorylated LRP6 and DVL2, active β-catenin, and total β-catenin. Significantly inhibited tumor growth in mice. |
| Animal Model: | Female BALB/c nude mice injected with MDA-MB-231 cells |
| Dosage: | 5 mg/kg |
| Administration: | Intraperitoneal injection; twice weekly; for 3 weeks |
Last Update：2024-04-09 21:01:54
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Mobile: 18021002903
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