832115-62-5
N-Cyclopropyl-5-(thiophen-2-yl)isoxazole-3-carboxamide
CAS: 832115-62-5
Molecular Formula: C11H10N2O2S
832115-62-5 - Names and Identifiers
832115-62-5 - Physico-chemical Properties
| Molecular Formula | C11H10N2O2S |
| Molar Mass | 234.27 |
| Density | 1.39±0.1 g/cm3(Predicted) |
| Boling Point | 468.1±35.0 °C(Predicted) |
| Solubility | Soluble in DMSO (up to 60 mg/ml) or in Ethanol (up to 16 mg/ml). |
| Appearance | solid |
| Color | Tan |
| pKa | 13.60±0.20(Predicted) |
| Storage Condition | -20° |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| In vitro study | In NSPCs, isoxazole 9 increases cell number and promotes cell differentiation. In OPCs, isoxazole 9 induces cell damage. In growing EPCs, isoxazole 9 reduced microtubule formation without affecting early EPCs. |
| In vivo study | In mice, isoxazole 9 (20 mg/kg, I. p.) crossing the blood-brain barrier and increasing neural stem cell proliferation and neurogenesis in hippocampal SGZ by a mef2-specific mechanism. Ioxazole 9 (20 mg/kg, I. p.) also increased the differentiation and dendritic complexity of immature neurons and improved memory. In MWM, isoxazole 9 improves spatial memory. |
832115-62-5 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 4.269 ml | 21.343 ml | 42.686 ml |
| 5 mM | 0.854 ml | 4.269 ml | 8.537 ml |
| 10 mM | 0.427 ml | 2.134 ml | 4.269 ml |
| 5 mM | 0.085 ml | 0.427 ml | 0.854 ml |
Last Update：2024-01-02 23:10:35
832115-62-5 - Reference Information
| biological activity | Isoxazole 9 (Isx-9) is a synthetic promoter of adult neurogenesis, they act by inducing neuronal differentiation of mature neural stem/precursor cells (NSPCs). Isoxazole 9 (Isx-9) can activate multiple signaling pathways, including TGF-β induced epithelial-mesenchymal transition signaling pathway (EMT), canonical and non-canonical Wnt signaling pathways at different stages of cardiac differentiation. |
Last Update：2024-04-09 15:16:56
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Spot supply
Product Name: N-Cyclopropyl-5-(thiophen-2-yl)isoxazole-3-carboxamide Visit Supplier Webpage Request for quotationCAS: 832115-62-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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