Name | Nefazodone |
Synonyms | SERZONE BMY-13754 NEFAZODONE MJ-13754-1 Nefazodone Nefazodone base l)-5-ethyl-4-(2-phenoxyethyl)- 3h-1,2,4-triazol-3-one,2,4-dihydro-2-3-(4-(3-chlorophenyl)-1-piperazinyl)propy 2-[3-[4-(3-CHLOROPHENYL)-1-PIPERAZINYL]PROPYL]-5-ETHYL-2,4-DIHYDRO-4-(2-PHENOXYETHYL)-3H-1,2,4-TRIAZOL-3-ONE HYDROCHLORIDE |
CAS | 83366-66-9 |
InChI | InChI=1/C25H32ClN5O2/c1-2-24-27-31(25(32)30(24)18-19-33-23-10-4-3-5-11-23)13-7-12-28-14-16-29(17-15-28)22-9-6-8-21(26)20-22/h3-6,8-11,20H,2,7,12-19H2,1H3 |
Molecular Formula | C25H32ClN5O2 |
Molar Mass | 470.01 |
Density | 1.23±0.1 g/cm3(Predicted) |
Melting Point | 180-182°C |
Boling Point | 599.6±60.0 °C(Predicted) |
Solubility | DMSO: ~11mg/mL at60°C |
Appearance | solid |
Color | white |
pKa | pKa 6.5 (Uncertain) |
Storage Condition | 2-8°C |
Physical and Chemical Properties | Crystallized from isopropanol-pentane, melting point 83-84 °c. Nefazodone Hydrochloride: C25H32C1N5O2? HCl. [82752-99-6]. Slow cooling from isopropyl alcohol to obtain polymorphic crystals, melting point 186.0~187.0 °c; Rapid cooling to obtain polymorphic crystals, melting point 181.0~182.0 °c. Crystallization from ethanol with a melting point of 175-177 °c has also been reported. |
Use | Used as an antidepressant |
Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
WGK Germany | 3 |