834903-43-4

Name	CID 16020046
Synonyms	CS-1189 C390-0219 CID16020046 CID 16020046 CID16020046 (CID 16020046) 4-[4-(3-Hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-4,6-dihydropyrrolo[3,4-c]pyrazol-5(1H)-yl]benzoic acid 4-[4,6-Dihydro-4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxopyrrolo[3,4-c]pyrazol-5(1H)-yl]-benzoic acid Benzoic acid, 4-[4,6-dihydro-4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxopyrrolo[3,4-c]pyrazol-5(1H)-yl]-
CAS	834903-43-4

Molecular Formula	C25H19N3O4
Molar Mass	425.44
Density	1.425±0.06 g/cm3(Predicted)
Boling Point	748.1±60.0 °C(Predicted)
Solubility	DMSO: soluble1mg/mL, clear (warmed)
Appearance	powder
Color	white to beige
pKa	4.27±0.10(Predicted)
Storage Condition	2-8°C
In vitro study	CID16020046 antagonized agonist-induced receptor activation in yeast cells expressing gpr55. CID16020046 antagonized LPI-mediated calcium release and activation of extracellular signal-regulated kinase in HEK293 cells stably expressing human gpr55, however, there was no such effect in HEK293 cells expressing CB1 or CB2. CID16020046 concentration-dependently inhibits LPI-induced activation of NFAT, NF-κB and seroreactive elements, inhibits translocation of NFAT and NF-κB and internalization of gpr55.
In vivo study	In a model of intestinal inflammation, CID16020046 improves the inflammatory response and reduces pro-inflammatory cytokines. CID16020046 did not alter exercise and Anxiety behavior in healthy mice.

Hazard Symbols	Xi - Irritant
Risk Codes	36/38 - Irritating to eyes and skin.
Safety Description	26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany	3

Last Update：2024-01-02 23:10:35

description	CID 16020046 is a GPR55 selective antagonist. It inhibits lpi-induced Ca2 + signaling, ERK1/2 phosphorylation, and gpr55-mediated activation of transcription factors. It has weak inhibitory effect on acetylcholinesterase, μ-opioid receptor, KCNH2 and hERG. It reduces the lpi-induced internalization of GPR55.
biological activity	CID16020046 (C390-0219) is a selective GPR55 antagonist, which can inhibit the inherent activity of GPR55. IC50 is 0.15 μM in yeast. CID16020046 has only weak activity on other GPCRs, ion channels, kinases and nuclear receptors.
target	TargetValue GPR55 (in east) 0.15 μM
Target	Value
GPR55 (in yeast)	0.15 μM
In vitro study	In yeast cells expressing GPR55, CID16020046 can antagonize receptor activation induced by agonists. CID16020046 antagonized LPI-mediated calcium release and extracellular signal-regulated kinase activation in HEK293 cells stably expressing human GPR55, but not in HEK293 cells expressing CB1 or CB2. CID16020046 concentration-dependent inhibition of LPI-induced activation of NFAT, NF-κB and serum response elements, inhibition of NFAT and NF-κB translocation and internalization of GPR55.
in vivo study	in intestinal inflammation model, CID16020046 improve inflammatory response and reduce pro-inflammatory cytokines. CID16020046 did not change the exercise and anxiety behaviors of healthy mice.

Last Update：2024-04-09 21:54:55

Product Name: CID 16020046 Visit Supplier Webpage Request for quotation
CAS: 834903-43-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

Product Name: CID 16020046 Visit Supplier Webpage Request for quotation
CAS: 834903-43-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

View History

834903-43-4

834903-43-4 Request for Quotation